Cartilage Glycoprotein-39 in Patients with Osteoarthritis in Combination with Cardiovascular Pathology

摘要

The article studies lipid parameters and inflammatory markers of OA without comorbidity, OA in combination with IHD, AH in conjunction with clinical symptoms of the disease. 110 patients with OA combined with IHD, AH, 30 patients with OA without comorbidity treated at the rheumatology department of the NOSMA clinics, and 30 healthy volunteers of identical gender and age were examined. The clinical parameters of gonarthritis, CGP-39, CRP, ESR, lipid profile (cholesterol, LDL, HDL, triglycerides, CA), and UDE results were analyzed. A significant increase in CGP-39 was observed in all the patients. The highest rates of CGP-39 were found in patients with the third stage of gonarthritis. Reliable direct correlations were found between CGP-39 and clinical indices of gonarthritis severity, CCA IMC thickness, the lipid spectrum, CRP, and ESR. CGP-39 can reflect OA severity. It can be regarded as a risk factor for OA and atherosclerosis development.