促性腺激素释放激素激动剂联合左炔诺孕酮宫内节育系统用于子宫内膜异位症术后效果

摘要

Objective To explore the effect of GnRH-a combined with Levonorgestrel intrauterine system in postoperative of endometriosis patients.Methods Fifty-six patients with endometriosis were collected and the treatment group and the contrast group by random number table method.Patients in the control group received the GnRH-a,and the contrast group received the GnRH-a combined with Levonorgestrel intrauterine system.The patients of two groups were followed up for one year.The dysmenorrhea score and serum CA125 are compared,and the rates of efficient and re-currence of two groups were evaluate and compared.Results The dysmenorrhea score and CA125 were lower than the preoperative (P <0.05).There was no significant difference between 1 year and postoperative 3 months,6 months,9 months (P >0.05),while the dysmenorrhea score and serum CA125 of control group at one year after operation are sig-nificantly higher than 3 months,6 months and 9 months after operation,the difference was statistically significant (P <0.05).The obsever group efficiency (82.14%),significantly higher than that in control group efficiency (64.29%), compared the two groups had a significant difference (P <0.05).The obsever group recurrence rate (7.14%),signifi-cantly lower than that in control group efficiency (39.29%),compared the two groups had a significant difference (P <0.05).Conclusion GnRH-a combined with Levonorgestrel intrauterine system can effectively improve the patient's pain,reduce the postoperative recurrence,improve the clinical curative effect among patients with endometriosis;is a kind of effective consolidation treatment.%目的：探讨促性腺激素释放激素激动剂（GnRH-a）联合左炔诺孕酮宫内节育系统在子宫内膜异位症（EMT）术后患者中的效果观察。方法选取 EMT 患者56例，均行腹腔镜手术治疗。按随机数字表法分为观察组（n ＝28）和对照组（n ＝28），对照组患者接受 GnRH-a 治疗，观察组患者接受 GnRH-a 联合左炔诺孕酮宫内节育系统治疗。对两组患者随访1年的痛经评分和血清 CA125，同时亦对两组患者的治疗有效率和复发率进行评估和比较。结果两组患者术后痛经评分以及 CA125值均低于术前（P ＜0．05），观察组的术后1年与术后3个月、6个月以及9个月比较，差异无统计学意义（P ＞0．05）。而对照组术后1年的痛经评分和 CA125值明显高于术后3个月、6个月以及9个月，差异有统计学意义（P ＜0．05）。观察组治疗有效率为82．14％，对照组为64．29％，两组比较差异有统计学意义（P ＜0．05）。观察组复发率为7．14％，远远低于对照组（39．29％），差异有统计学意义（P ＜0．05）。结论 GnRH-a 联合左炔诺孕酮宫内节育系统治疗 EMT 术后患者，可有效改善患者的疼痛程度，并减轻术后复发的情况，提高了临床疗效。