目的 探讨呼出气一氧化氮(FeNO)检测在指导慢性阻塞性肺疾病(COPD)患者吸入性糖皮质激素治疗中的临床价值.方法 选择行糖皮质激素吸入治疗的COPD患者120例为研究对象,采用随机数字表法,将其分为研究组(根据FeNO检测结合其他相关指标调整治疗)和对照组(根据经验调整治疗),每组各60例患者.随访半年,观察比较两组患者的治疗效果.结果 两组患者的稳定期持续时间、急性发作次数以及肺功能各项指标,差异无统计学意义(P>0.05),而研究组患者药物治疗费用[(4319.3±227.6)元]显著少于对照组[(5104.2±324.5)元],差异有统计学意义(P<0.05).结论 FeNO检测能够为吸入性糖皮质激素治疗的COPD患者提供可靠的指导依据,在保证治疗效果的同时,能够减少患者的药物治疗费用.%Objective To explore the clinical value of FeNO (Fractional exhaled nitric oxide) detection in patients with chronic obstructive pulmonary disease (COPD) treated by inhaled corticosteroids.Methods One hundred and twenty patients with COPD were treated with glucocorticoid inhalation were selected from January 2015 to March 2016 in our hospital and randomly divided into two groups by random number table method.The patients were followed up for six months to observe the effect of two groups.Results The duration of stable phase,the number of acute exacerbations and the pulmonary function of two set of patients had no statistics significance(P>0.05).The cost of drug treatment in the study group was significantly less than that in control group (P<0.05).Conclusion FeNO detection can provide a reliable guideline for the COPD patients treatment with glucocorticoid inhalation,meanwhile,which can reduce the patient's costs of medication.
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