门冬氨酸钾镁联合胺碘酮对慢性心力衰竭并室性心律失常患者心功能的影响

摘要

目的 探讨门冬氨酸钾镁联合胺碘酮对慢性心力衰竭并室性心律失常患者心功能的影响.方法 选择232例慢性心力衰竭并室性心律失常患者,用随机数字法分为观察组和对照组,每组116例.对照组采用胺碘酮治疗,观察组在胺碘酮基础上加用门冬氨酸钾镁.治疗前后,检测两组患者的血压、心率、P-R与Q-T间期、左室舒张末期内径(LVD)、左室射血分数(LVEF)、室后壁厚度(LVWP),并统计治疗效果和不良反应发生率.结果 治疗后,两组心率均明显降低,P-R与Q-T间期明显增加(P<0.05),观察组心率、P-R间期和Q-T间期较对照组,均P<0.05;治疗后,两组LVD、LVEF、LVWP均明显改善(P<0.05),且观察组LVD、LVEF和LVWP改善效果显著优于对照组(P<0.05);治疗后,观察组总有效率为83.6%,显著高于对照组的72.4% (χ2=4.247,P<0.05).结论 门冬氨酸钾镁联合胺碘酮可有效缓解慢性心力衰竭并室性心律失常患者的心脏收缩和舒张功能,减慢心率,恢复正常射血,改善患者临床症状.%Objective To investigate the effect of potassium magnesium aspartate combined amiodarone on cardiac functionof chronic heart failure with ventricular arrhythmia patients.Methods 232 cases of chronic heart failure with ventricular arrhythmia patients were randomly divided into observation group and control group,each group 116 cases.Patients in control group were given amiodarone,and patients in observation group were given potassium magnesium aspartate based on amiodarone.Before and after treatment,the blood pressure,heart rate,PR and QT interval,left ventricular end diastolic diameter (LVD),left ventricular ejection fraction (LVEF),left ventricular posterior wall thickness (LVWP) of two groups were detected,and the efficacy and adverse reaction were accounted.Results After treatment,heart rate of two groups were significantly reduced,PR and QT levels interval were significantly increased (P<0.05),and heart rate reduce of observation group was significantly better than that of control group,P-R and Q-T interval increase of observation group were significantly better than those of control group (P<0.05).After treatment,the LVD,LVEF and LVWP of two groups were significantly improved(P<0.05),and the LVD,LVEF and LVWP improvement of observation group were significantly better than those of control group(P<0.05).The efficiency of observation group was 83.6%,which was significantly higher than that of control group(72.4%),P<0.05.Conclusion Potassium magnesium aspartate combined amiodarone could effectively relieve cardiac systolic and diastolic function of chronic heart failure with ventricular arrhythmia,slow down the heart rate and restore normal ejection,with satisfactory treatment.