Effect of bisoprolol in combined with trimetazidine on the cardiac function rehabilitation in patients with chronic heart failure

摘要

Objective: To explore the effect of bisoprolol in combined with trimetazidine on the cardiacfunction rehabilitation in patients with chronic heart failure (CHF). Methods: A total of 84patients with CHF who were admitted in our hospital from November, 2015 to October,2016 were included in the study and randomized into the observation group and the controlgroup. The patients in the two groups were given oxygen inhalation, lipid regulation, diuresis,ARB, and other routine treatments. Digitalis preparations were given for those who had poorcardiac function, and bisoprolol were orally administrated in the same time. On the abovebasis, the patients in the observation group were given trimetazidine dihydrochloride tablets,continuously for 3 months. The morning fasting peripheral venous blood before and aftertreatment in the two groups was collected. CRP, IL-6, TNF-α, BNP, NE, AngⅡ, ANP, ALD,and ET were detected. The cardiac color Doppler ultrasound diagnostic apparatus was used todetect LVPWT, PWS, PWD, IVSS, and IVMI. Results: CRP, IL-6, TNF-α, and BNP levelsafter treatment in the observation group were significantly lower than those in the controlgroup. NE, AngⅡ, ANP, ALD, and ET levels after treatment in the observation group weresignificantly lower than those in the control group. LVPWT, PWS, PWD, IVSS, and IVMIlevels after treatment in the observation group were significantly lower than those in the controlgroup. Conclusions: Bisoprolol in combined with trimetazidine can significantly reducethe inflammatory reaction in patients with CHF, and effectively regulate the neuroendocrinestability in order to reverse or reduce VR and improve the left ventricular function.