新型双膦配体的合成及其在2-丁烯氢甲酰化反应中的应用

摘要

A new biphosphorus ligand has been developed and applied in the thodium-catalyzed regioselective hydroformylation of 2-butene. The effects of ligand/Rh ratio. reaction temperature, reaction pressure. and substrate/catalyst molar ratio were investigated. High activity and regioselectivity were achieved. The n-aldehyde/iso-aldehyde ratio of about 28.5 was obtained at 60 ℃. and the TOF increased to 660 h-1 at the pressure of 2.0 MPa.%合成了以联苯为骨架,以吲哚为取代基的双膦配体,并研究了该配体与Rh(acac)(CO)2原位生成的催化剂在2-丁烯氧甲酰化反应中的催化性能.考察了膦/铑比、反应温度、反应压力以及2-丁烯与Rh(acae)(CO)2摩尔比等因素对反应活性及区域选择性的影响.结果表明,在60℃反应时,醛的正异比高达28.5;当压力为2.0MPa时,反应TOF值可达660h-1.