急性心肌梗死患者血浆中 MEG3 和 UCA1 的表达水平及临床意义

摘要

Objective :To explore plasma expression levels of human maternal expression gene 3 (MEG3) and urotheli-al carcinoma antigen 1 (UCA1) in patients with acute myocardial infarction (AMI) and their clinical significance . Methods : A total of 90 AMI patients treated in our hospital were enrolled as AMI group ,and 50 healthy subjects un-dergoing physical examination in our hospital simultaneously were treated as healthy control group .Plasma expres-sions of MEG3 and UCA1 ,serum levels of creatine kinase isoenzyme MB (CK-MB) and cardiac troponin I (cTnI) were observed and compared between healthy control group and AMI group on 1h ,3h ,6h and 12h after onset . Spearman correlation analysis was used to analyze their correlation .Results : Compared with healthy control group , there was significant rise in plasma MEG3 expression [ (0-002 ± 0-001) vs .0-017 ± 0-003)] ,and significant reduc-tion in UCA1 expression [ (0-027 ± 0-005) vs .(0-017 ± 0-002)] in AMI group on 1h after onset , P＝0-001 both ;after 3h ,there were significant rise in serum levels of CK-MB [ (20-01 ± 3-05) IU／L vs.( (32-10 ± 4-40) IU／L] and cTnI [ (1-01 ± 0-87) ng／L vs.(2-10 ± 0-91) ng／L] in AMI group , P＝0-001 all.Spearman correlation analy-sis indicated that in plasma MEG3 expression was significant positively correlated with serum CK-MB and cTnI levels ( r＝0-351 ,0-368 , P＜0-05 both) ,and plasma UCA1 expression was significant inversely correlated with serum levels of CK-MB and cTnI (r＝ －0-416 ,－0-425 , P＜0-01 both) AMI patients .Conclusion : Plasma MEG3 level significant rises ,and UCA1 level significantly reduces in AMI patients during early onset period .Both are signifi-cantly correlated with CK-MB and cTnI levels ,which may be used as new markers diagnosing early AMI .%目的:探讨急性心肌梗死(AMI)患者血浆中人类母系表达基因3 (MEG3)和尿路上皮癌抗原1 (UCA1)表达水平及其临床意义.方法:选择我院收治的90例AMI患者为AMI组,同时期50例在我院体检健康者为健康对照组,观察并比较健康对照组及AMI组发病后不同时间点(1h 、 3h 、 6h 、 12h)血浆MEG3 、 UCA1表达及血清肌酸激酶同工酶(CK-MB)和心肌肌钙蛋白I (cTnI)水平变化,采用Spearman相关分析其相关性.结果:与健康对照组比较, AMI患者发病1h后血浆MEG3 [ (0-002 ± 0-001)比0-017 ± 0-003)]表达显著升高, UCA1 [ (0-027 ± 0-005)比(0-017 ± 0-002)]表达显著降低( P均＝0-001) ; 3h后AMI患者血清CK-MB [ (20-01 ± 3-05) IU／L比(32-10 ± 4-40) IU／L] 、 cTnI [(1-01 ± 0-87) ng／L比(2-10 ± 0-91) ng／L]水平均显著升高(P均＝0-001) . Spearman相关分析显示: AMI患者血浆 MEG3表达与血清 CK-MB 、 cTnI水平呈显著正相关( r＝0-351 、 0-368 , P均＜0-05 ) ;而血浆 UCA1 表达与血清 CK-MB 、 cTnI水平呈显著负相关( r＝ －0-416 、－0-425 , P均＜0-01) .结论:急性心肌梗死发作早期患者血浆中人类母系表达基因-3显著升高,尿路上皮癌抗原1显著降低,两者与CK-MB 、 cTnI水平有显著相关性,可作为急性心梗早期确诊的新型标志物.