冠心病患者血浆肿瘤坏死因子-α和单核细胞趋化蛋白-1含量的变化及其意义

摘要

目的：探讨肿瘤坏死因子‐α（TNF‐α）及单核细胞趋化蛋白‐1（MCP‐1）在冠心病心绞痛发病机制中的作用。方法：选择冠状动脉造影确诊的冠心病患者60例，分为稳定型心绞痛（S A P ）组（28例），不稳定型心绞痛（U A P ）组（32例），30例冠状动脉造影正常者作为正常对照组。分别采用免疫浊度法和酶联免疫吸附法检测血浆TNF‐α、MCP‐1水平。结果：与正常对照组比较，SAP组和 UAP组血浆 TNF‐α[（15.18±4.12） ng／L 比（18.56±4.22） ng／L比（21.79±4.43） ng／L]、MCP‐1[（10.23±3.21） pg／L比（14.67±3.42） pg／L比（17.86±3.51） pg／L]水平明显升高（P均＜0.01），且UAP组TNF‐α、MCP‐1水平显著高于SAP组（P均＜0.01）。结论：冠心病患者的血浆肿瘤坏死因子‐α与单核细胞趋化蛋白‐1水平显著升高，对预测冠心病的存在和发展有重要临床意义。%Objective:To explore the role of tumor necrosis factor‐α(TNF‐α) and monocyte chemoattractant protein‐1 (MCP‐1) in pathogenesis of angina pectoris of coronary heart disease (CHD) .Methods :A total of 60 CHD pa‐tients diagnosed by coronary angiography (CAG) were selected and divided into stable angina pectoris (SAP) group (n=28) and unstable angina pectoris (UAP) group (n=32) ,and another 30 cases with normal CAG results were re‐garded as normal control group .Immune turbidity method and enzyme linked immunosorbent assay were used to measure plasma levels of TNF‐αand MCP‐1 respectively .Results:Compared with normal control group ,there were significant rise in plasma levels of TNF‐α[ (15.18 ± 4.12) ng/L vs .(18.56 ± 4.22) ng/L vs .(21.79 ± 4.43) ng/L] and MCP‐1 [(10.23 ± 3.21) pg/L vs .(14.67 ± 3.42) pg/L vs .(17.86 ± 3.51) pg/L] in SAP group and UAP group , P<0.01 all ,and those of UAP group were significantly higher than those of SAP group , P<0.01 both .Conclusion:Plasma tumor necrosis factor‐αand monocyte chemoattractant protein‐1 levels significantly rise ,it possesses impor‐tant clinical significance for predicting existence and development of coronary heart disease .