目的 评估糖尿病与非糖尿病血液透析患者血清全段甲状旁腺激素(intact parathyroid hormone,iPTH)水平的差异及其在长期血液透析中的变化.方法 维持性血液透析患者89例,检测血清PTH值.将患者分为糖尿病肾病(diabetic nephropthy,DN)组(20例)、非糖尿病肾病合并糖尿病组(6例)与非糖尿病组(63例);根据患者透析龄的长短将各组分为短期组(透析龄＜5年)与长期组(透析龄≥ 5年);分析各组iPTH水平之间的差异.结果 DN组的iPTH水平低于其它2组,具有显著性差异(P ＜ 0.05和P ＜0.01);非糖尿病组的iPTH水平在长期透析龄组中明显升高,高于其他各组,具有显著性差异(P＜0.05).结论 DN非糖尿病肾病血液透析患者具有较低的血清iPTH水平,长期血液透析患者 iPTH水平的升高在非糖尿病患者中表现更显著.%Objectives This study evaluated the differences in serum intact parathyroid hormone (iPTH) level and its change in the hemodialysis course between diabetic and non-diabetic hemodialysis patients. Methods A total of 89 maintenance hemodialysis patients were surveyed in this study. Serum iPTH level was measured. Patients were divided into diabetic nephropathy (DN, n=20), non-diabetic nephropathy with diabetes group (n=6), and non-diabetic group (n=63). Patients in a group were subdivided into short dialysis age group (dialysis age ＜ 5 years) and long dialysis age group (dialysis age =5 years). iPTH level and clinical data were compared among the groups. Results Serum iPTH was significantly lower in DN group than in non-diabetic nephropathy with diabetes group and non-diabetic group (P ＜ 0.05 and P ＜ 0.01, respectively). iPTH level was significantly higher in non-diabetic patients with long dialysis age than other groups (P＜0.05). Conclusions Serum iPTH level was lower in DN group than in non-diabetic nephropathy group. iPTH level increased in patients with longer dialysis age, especially in those with non-diabetic nephropathy.
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