持续性腹膜透析患者体内维生素D的含量对铁代谢的影响

摘要

The prevalence of vitamin D deficiency or inadequate vitamin D intake is very high in patients on continuous ambulatory peritoneal dialysis (CAPD).Iron metabolism disturbance is aggravated due to the accumulation of hepcidin,which is resulted from the vitamin D deficiency induced abnormal bone mineral metabolism,micro-inflammation and malnutrition in CAPD patients.Supplement of vitamin D may be useful for iron metabolism disturbance through improvement of abnormal metabolism and malnutrition status and decrease of hepcidin in CAPD patients.%持续性不卧床腹膜透析(continuous ambulatory peritoneal dialysis,CAPD)患者维生素D缺乏或不足的患病率极高,由于维生素D的缺乏加重了CAPD患者体内骨矿物质代谢的异常、微炎症反应及营养状态的异常,从而导致体内铁调素(hepcidin)的蓄积,加重患者体内的铁代谢紊乱.我们通过对CAPD患者补充维生素D,从而改善患者体内的异常代谢状态及营养情况,减少hepcidin的蓄积,可能对CAPD患者铁代谢的异常有一定治疗价值.