大肠杆菌利用合成生物学策略生产聚羟基脂肪酸酯的研究进展

摘要

As a rapidly developmental interdiscipline,synthetic biology offers powerful tools for microbial synthesis. Microbial cell factories can synthesize a variety of polyhydroxyalkanoates (PHA). The diversity of PHA can be explored and the cost of PHA production can be reduced using strategies of synthetic biology in Escherichia coli. In addition, PHA yield can be increased. We review here the progress in production of PHA via strategies of synthetic biology in E. coli and indicate the research and application prospects of PHA.%合成生物学作为近年来发展迅速的一门交叉学科,为微生物的生物合成提供了强有力的平台工具.微生物细胞工厂可以合成一系列不同种类的聚羟基脂肪酸酯(PHA),而大肠杆菌作为最常用的底盘,正不断运用合成生物学的策略发掘PHA的多样性并降低成本、提高产量.本文中,笔者综述了大肠杆菌利用合成生物学策略生产生物基材料PHA的研究进展,并对其开发与应用前景进行了展望.