川芎嗪注射液辅佐1，6-二磷酸果糖治疗新生儿缺氧缺血性脑病的疗效及预后观察

摘要

Objective To probe into clinical application value of tetramethylpyrazine injection as an adjuvant of 1,6-diphosphate in the treatment of neonatal hypoxic-ischemic encephalopathy.Methods From January 2012 to December 2012,98 neonatal hypoxic-ischemic encephalopathy children patients were selected in the Second Affiliated Hospital of Shenyang Medical College.The children patients were divided into observation group and control group randomly.There were 49 cases in each group.Both two groups adopted 1 ,6 diphosphate - fructose,and the observation group adopted ligustrazine injection on the basis of control group.The clinical treatment and prognosis of the children patients in two groups were compared and analyzed.Results The rates of significant efficiency and total efficiency were 67.35%and 93.88%in observation group,which were higher than those in control group (51.02%,71.43%),and there were statistically significant (P <0.05 );compared with control group,the NBNA scores of observation group were improved significantly after 3rd,7th and 14th days treatment,and there were statistically significant (P<0.05);compared with control group,the ratio of cerebral palsy,epilepsy,mental retardation and death in observation group showed different degree of reduction,but there were no statistically significant.Conclusion The effect of tetramethylpyrazine injection adjuvant 1 ,6-diphosphate in treatment of neonatal hypoxic-ischemic encephalopathy was effective and significant.It has positive role in promoting the improvement and upgrading of the clinical efficacy and prognosis.%目的：探讨川芎嗪注射液辅佐1，6-二磷酸果糖在新生儿缺氧缺血性脑病患儿中的临床应用价值。方法选取2012年1月～2012年12月期间沈阳医学院附属第二医院收治的新生儿缺氧缺血性脑病患儿98例，将患儿随机分为观察组和对照组，每组患儿49例，2组患者均采用1，6-二磷酸果糖进行临床药物治疗，观察组在对照组用药的基础上加用川芎嗪注射液，并分别对2组患儿的临床治疗情况和预后情况进行比较和分析。结果观察组显效的比率和总有效率分别为67.35％、93.88％，均明显高于对照组的51.02％、71.43％，差别均具有统计学意义（P＜0.05）；观察组经药物治疗后的第3、7、14天的新生儿神经行为评分（neonatal behavioral neurological assessment，NBNA）值较对照组均显著提升，差别均具有统计学意义（P＜0.05）；观察组发生脑瘫、癫痫、智力低下及死亡的比率较对照组均呈现出不同程度的降低，但差别均不具有统计学意义。结论川芎嗪注射液辅佐1，6-二磷酸果糖治疗新生儿缺氧缺血性脑病，其疗效确切，效果显著，同时对于临床疗效及预后效果的改善和提升均具有积极的促进作用。