不同剂量缓释茶碱对小儿哮喘前白蛋白、C-反应蛋白及白细胞计数的影响

摘要

Objective To analyse effect of different dose of sustained-release theophyline on prealbumin, C-reactive protein and white blood cell count in patients with pediatric asthma.Methods 58 children with acute asthma attack in our hospital were collected.All children were randomly divided into high dose group and low dose group,29 cases in each group.On the basis of conventional treatment, high dose group were treated with high dose theophylline sustained release tablets 5 mg/kg, one times per eight hours,orally,and low dose group was treated with low dose theophylline sustained release tablets,2 mg/kg, one times per eight hours,orally.Two groups were treatment for two weeks.After the treatment, the serum levels of pre albumin, C-reactive protein and veinal blood level of white blood cell count were detected in all children.Results Compared with high dose group post-treatment, the serum level PA was higher in low dose group (P<0.05);the serum level of CRP was lower in low dose group (P<0.05);the veinal blood level of WBC, percentage of neutrophils and percentage of eosinophils was lower in low dose group (P<0.05) .Conclusion Compared with high dose of sustained-release theophyline,the low dose of sustained-release theophyline can significantly reduce the serum CRP level and veinal blood level of WBC, percentage of neutrophils and percentage of eosinophils, improve serum PA level in patients with pediatric asthma, reduce inflammation in patients.%目的 探讨不同剂量缓释茶碱对小儿哮喘前白蛋白(prealbumin,PA)、C-反应蛋白(C-reaction protein,CRP)及白细胞计数(white blood cell cout,WBC)的影响.方法 收集杭州余杭区第一人民医院儿科收治的哮喘急性发作期的患儿58例,随机分为高剂量组和低剂量组,每组各29例,在常规治疗基础上,高剂量组患儿给予高剂量茶碱缓释片口服治疗,5 mg/kg,每8 h一次口服.低剂量组给予小剂量茶碱缓释片口服治疗2 mg/kg,每8 h一次口服.2组患儿均治疗2周.治疗结束后,对所有患儿的血清前白蛋白、C-反应蛋白水平及静脉血白细胞计数水平相关指标进行检测.结果 与高剂量组治疗后比较,低剂量组患儿血清PA水平较高(P<0.05);低剂量组患儿的血清CRP水平较低(P<0.05);低剂量组患儿的静脉血静脉血WBC、中性粒细胞百分比、嗜酸性粒细胞百分比较低(P<0.05).结论 低剂量缓释茶碱与高剂量相比,能够更显著降低哮喘患儿的血清CRP水平及静脉血WBC、中性粒细胞百分比、嗜酸性粒细胞百分比,提高血清PA水平,减轻患儿炎症状态.