rt-PA静脉溶栓对脑梗死早期患者血清神经特异性烯醇酶、C反应蛋白及脂肪酸结合蛋白水平影响研究

摘要

目的：探讨rt-PA静脉溶栓对脑梗死早期患者血清神经特异性烯醇酶（ NSE）、C反应蛋白（ CRP）及脂肪酸结合蛋白水平（ FABP）的影响。方法收集大连市中心医院收治的急性脑海梗死患者54例，随机分为对照组和实验组，每组27例，2组均给予降低颅内压、改善循环、营养脑细胞常规治疗，对照组在此基础上给予低分子肝素钙注射液5000 U皮下注射，1次／12 h，连续7 d ；实验组在对照组基础上，给予注射用阿替普酶（ rt-PA）溶栓治疗，连续7 d，治疗结束后，对所有患者的NSE、CRP及FABP水平进行检测。结果与对照组治疗后比较，实验组患者血清CRP、NSE和FABP水平显著降低（P＜0.05）。结论 rt-PA静脉溶栓能够显著降低脑梗死早期患者血清NSE、CRP及FABP水平，改善患者预后，对临床有指导意义。%Objective To analyse effect of rt-PA intravenous thrombolytic therapy on serum levels of neuro-specific endolase, C-reactive protein and fatty acid binding protein in patients with early cerebral infarction.Methods 54 patients who were diagnosed with early acute cerebral infarction in Dalian Municipal Central Hospital were collected.All patients were randomly divided into experimental group and control group,27 cases in each group.Two groups were given conventional treatment,such as reduction of intracranial pressure,improve circulation and nutrition brain cells.Control group was given low molecular weight heparin calcium injection 5000U, one times per 12 h for 7 consecutive days, and experimental group was given rt-PA intravenous thrombolytic therapy on the basis of the control group for 7 consecutive days, post-treatment,the serum levels of NSE, CRP and FABP were detected in all patients.Results Compared with control group post-treatment, the serum CRP,NSE and FABP level was lower in experimental group ( P<0.05).Conclusions The rt-PA intravenous thrombolytic therapy can significantly reduce the serum CRP, NSE and FABP levels in the patients with early cerebral infarction, improve the prognosis of patients.