前列舒通胶囊联合坦索罗辛对良性前列腺增生患者血清睾酮、雌二醇水平的影响及其临床疗效研究

摘要

目的：探讨前列舒通胶囊联合坦索罗辛治疗良性前列腺增生（ benign prostatic hyperplasia，BPH）的临床疗效及其对患者血清睾酮和雌二醇水平的影响。方法114例BPH患者随机分为对照组（n＝54）和观察组（n＝60）。对照组给予坦索罗辛治疗，观察组在对照组的基础上联合应用前列舒通胶囊治疗。比较2组患者临床疗效、相关指标改善情况、血清睾酮、雌二醇水平及不良反应发生情况。结果观察组的治疗总有效率为95．0％，明显高于对照组83．3％的总有效率（ P＜0．05）。与对照组相比，观察组治疗后国际前列腺症状评分（ international prostate symptom score，IPSS）、残余尿量（ residual urine，Ru）、前列腺体积（ prostate volume，PV）等指标显著降低，最大尿流率（maximum flow rate，Qmax）指标显著升高，雌二醇水平明显上升，比较差异都有统计学意义（P＜0．05），而睾酮水平2组间比较无统计学差异。治疗过程中，均未出现严重不良反应，观察组的不良反应发生率为13．3％，与对照组11．1％的不良反应发生率比较，差异无统计学意义（ P＞0．05）。结论前列舒通胶囊联合坦索罗辛治疗BPH疗效可靠，能够显著提高临床疗效，改善临床指标，调节性激素水平，且不良反应轻微，临床上值得进一步研究。%Objective To investigate the clinical effect of QianlieShutong capsule in combination with tamsulosin in the treatment of benign prostatic hyperplasia ( BPH) and its effects on serum testosterone and estrogen.Methods 114 cases of BPH were randomly divided into control group (n=54) and observation group (n=60).The control group were treated with tamsulosin, while the observation group were treated with QianlieShutong capsule in combination with tamsulosin.Then, the curative efficacy, improvement of related indexes, level of serum testosterone, estrogen and adverse reactions were compared.Results The observation group had a total therapeutic efficacy ratio of 95.0%, which was statistically higher than that of 83.3% in control group (P<0.05).In comparison with control group after the treatment, international prostate symptom score (IPSS), residual urine (Ru), prostate volume (PV) in observation group statistically decreased, and maximum flow rate (Qmax), level of estrogen increased (all P<0.05), while level of testosterone in two groups was statistically same.During the treatment, there’ s no case of severe adverse reaction.And the incidence of adverse reactions in the observation group was 13.3%, which was statistically same with that of 11.1% in control group.Conclusion Combined treatment of QianlieShutong capsule and tamsulosin is effective for BPH, which can significantly increase curative efficacy, improve related indexes and regulate level of sexual hormone with minor adverse reactions.