氟比洛芬酯在子宫肌瘤患者体内的药物代谢分布及对前列腺素E2的影响

摘要

Objective To investigate drug metabolism distribution of flurbiprofen axetil(FA) in uterine fibroids and its effect on prostaglandin E2 (PGE2).Methods A total of 86 patients with uterine fibroids from January 2014 to February 2016 in The NO.2 Hospital of Ningbo were randomly divided into control group of 44 cases and observation group of 42 cases.The control group and the observation group were given 0.9% sodium chloride solution and 1 mg/kg FA at 15 min before operation,detection of the active metabolite of FA flurbiprofen (FP),and the concentration of PGE2 in tissue homogenate was detected by ELISA.Results The observation group FP concentration of normal and tumor tissue were (0.70 ±0.13)μg/mL and (1.72 ± 0.13)μg/mL,significantly higher than the control group(0.00 ±0.00)μg/mL and (0.00 ±0.00)μg/mL, the difference was statistically significant(P<0.05), the FP concentration of tumor tissue in the observation group was significantly higher than that in the normal group, the difference was statistically significant(P<0.05), the normal tissue and tumor tissue PGE2 concentration in the observation group were (189.29 ±26.38) pg/mL and (260.01 ±46.63) pg/mL,which were significantly lower than those in the control group(210.03 ±35.22)pg/mLand(390.20 ±92.10)pg/mL, the difference was statistically significant(P<0.05), the observation group plasma FP was (5.50 ±0.72)μg/mL,significantly higher than the control group (0.00 ±0.00)μg/mL, the difference was statistically significant(P <0.05),and PGE2 was (602.38 ±84.09) pg/mL,significantly lower than the control group(920.13 ±89.05)pg/mL, the difference was statistically significant(P <0.05).Conclusion FA in the uterine fibroids have a certain distribution of targeted,can reduce the concentration of PGE2 ,so as to alleviate the pain of patients.%目的：探讨氟比洛芬酯（flurbiprofen axetil，FA）在子宫肌瘤的药物代谢分布及对前列腺素E2（prostaglandin E2，PGE2）的影响。方法选取2014年1月～2016年2月在宁波市第二医院因子宫肌瘤行子宫全切术的患者86例，随机分为对照组44例和观察组42例。对照组和观察组分别于术前15 min 给予0.9％氯化钠溶液和1 mg／kg FA，检测 FA 的活性代谢物氟比洛芬（flurbiprofen，FP），酶联免疫吸附剂测定（enzyme linked immunosorbent assay ，ELISA）法检测组织匀浆中PGE2的浓度。结果观察组正常组织和肿瘤组织FP浓度分别为（0.70±0.13）μg／mL和（1.72±0.13）μg／mL，明显高于对照组（0.00±0.00） g／mL和（0.00±0.00）μg／mL，差异有统计学意义（P＜0.05）；观察组肿瘤组织FP浓度明显高于正常组织，差异有统计学意义（P＜0.05）；观察组正常组织和肿瘤组织PGE2浓度分别为（189.29±26.38）pg／mL和（260.01±46.63）pg／mL，均明显低于对照组（210.03±35.22）pg／mL和（390.20±92.10）pg／mL，差异有统计学意义（P＜0.05）；观察组血浆FP浓度为（5.50±0.72）μg／mL，明显高于对照组（0.00±0.00）μg／mL，差异有统计学意义（P＜0.05），而PGE2浓度为（602.38±84.09）pg／mL，明显低于对照组（920.13±89.05）pg／mL，差异有统计学意义（P＜0.05）。结论 FA在子宫肌瘤组织中有一定的靶向分布，可降低PGE2浓度，从而起到减轻患者痛觉的作用。