血塞通滴丸联合前列地尔对老年慢性充血性心力衰竭患者血清脑利钠肽的影响

摘要

Objective To investigate the effect of Xuesetong Dripping Pills combined with alprostadil intervention on serum brain natriuretic peptide in elderly patients with chronic congestive heart failure.Methods In 74 patients with chronic congestive heart failure, were randomly divided into observation group and control group, 37 cases in each group.Control group received conventional method.The observation group received Xuesetong Dripping Pills combined with alprostadil on the basis of conventional therapy.Compared the efficacy, the heart function level, walking test and level of serum brain natriuretic peptide between two groups after 15 days’ treatment.Results The total efficiency of observation group was 94.59%, which was higher than 75.68% in the control group, the difference was statistically significant(P<0.05).After treatment, the heart function level improvement in the observation group was better than the control group, the difference was statistically significant(P<0.05).After treatment, 6 min walking test in the observation group(316.4 ±20.7) m, was better than the control group(303.5 ±28.1) m, the difference was statistically significant(P<0.05).The level of serum brain natriuretic peptide in the observation group(608.9 ±158.1)ng/L, was lower than that of the control group(792.7 ±179.4) ng/L, the difference was statistically significant ( P <0.05 ) .Conclusion Xuesetong Dripping Pills combined with alprostadil has good curative effect in the treatment of chronic congestive heart failure,can relieve the abnormal increase of serum brain natriuretic peptide, improve blood circulation and heart function.%目的：探讨血塞通滴丸联合前列地尔治疗老年慢性充血性心力衰竭患者的疗效及对血清脑利钠肽（ brain natriuretic peptide，BNP）的影响。方法慢性充血性心力衰竭患者74例，随机分为2组，各37例。对照组给予常规方法治疗，观察组在常规方法治疗基础上给予血塞通滴丸联合前列地尔治疗。2组均治疗15 d，观察比较2组疗效、心功能、步行试验和血清脑利钠肽。结果观察组患者总有效率为94.59％，高于对照组的75.68％，差异有统计学意义（ P＜0.05）。治疗后，观察组患者心功能水平改善情况优于对照组，差异有统计学意义（P＜0.05）。治疗后，观察组患者6 min步行试验（320.4±20.7）m优于对照组（303.5±28.1）m，差异有统计学意义（P＜0.05）。观察组患者血清脑利钠肽水平（608.9±158.1）ng／L低于对照组（792.7±179.4）ng／L，差异有统计学意义（ P＜0.05）。结论血塞通滴丸联合前列地尔治疗慢性充血性心力衰竭疗效显著，能够缓解患者血清脑利钠肽异常升高，改善血液循环和心功能。