宁动颗粒联合氟哌啶醇对抽动秽语综合征患儿的治疗效果及细胞免疫功能的影响

摘要

Objective To investigate the clinical effect and changes in cellular immune of children with Tourette 's syndrome in treatment with Ningdong granule and haloperidol.Methods 48 cases of children with Tourette's syndrome from February 2015 to February 2016 in hospital were selected and randomly divided into the observation group and control group with 24 cases in each group.The patients of two groups were all treated with conventional treatment, including mental relaxation, reverse muscle relaxation therapy and self-training.The patients of control group were treated with haloperidol, and on the basis of the control group, the patients of observation group were treated with Ningdong granule.The clinical effect, the levels of TNF-ɑ, IL-12, CD3, CD4, CD8, CD4/CD8 were compared before and after treatment between two groups, and recorded the incidence of adverse reactions in two groups of children.Results After the treatment, the total effective rate of the observation group was 91.6%, which was significantly better than the control group 66.6%, the difference was statistically significant (P<0.05).The levels of TNF-ɑ, IL-12, CD8 of the observation group were significantly lower than those of the control group (P<0.05), the levels of CD3, CD4, CD4/CD8 of the observation group were significantly higher than those of the control group, the difference was statistically significant (P<0.05).There were constipation, dizziness, drowsiness, fatigue, poor appetite, tachycardia and other adverse reactions occurred in both two groups, and the incidence of adverse reactions in the observation group was significantly lower than that in the control group, the difference was statistically significant (P<0.05).Conclusion The combination of Ningdong granule and haloperidol in the treatment of children with Tourette 's syndrome is effective and can improve the cellular immune function .%目的 探讨抽动秽语综合征患儿应用宁动颗粒和氟哌啶醇治疗效果及对细胞免疫功能的影响.方法 选取2015年2月~2016年2月宁波市医疗中心李惠利东部医院收治的48例抽动秽语综合征患儿为研究对象,随机分为观察组和对照组,每组各24例.2组患儿均接受心理精神放松,反向肌群松弛疗法及自我训练等常规治疗.对照组在常规治疗基础上口服氟哌啶醇,观察组在对照组基础上给予宁动颗粒.比较2组患儿临床效果,治疗前后肿瘤坏死因子-α(TNF-ɑ)、白细胞介素-12(IL-12)、CD3、CD4、CD8、CD4/CD8的水平变化情况,并记录2组患儿不良反应发生情况.结果 治疗后观察组总有效率91.6%,显著高于对照组的66.6%,差异有统计学意义(P<0.05);观察组TNF-ɑ、IL-12、CD8水平明显低于对照组,CD3、CD4、CD4/CD8显著高于对照组,差异有统计学意义(P<0.05);2组患儿治疗过程均发生便秘、头晕、嗜睡、乏力、纳差、心动过速等不良反应,观察组各不良反应发生情况明显低于对照组,差异有统计学意义(P<0.05).结论 宁动颗粒联合氟哌啶醇治疗抽动秽语综合征患儿疗效确切,能有效提高机体细胞免疫功能.