羟苯磺酸钙片联合甲钴胺注射液治疗糖尿病周围神经病变的疗效观察及对氧化应激和神经营养因子的影响

摘要

Objective To investigate the calcium dobesilate tablets combined with mecobalamin injection in treatment of diabetic peripheral neuropathy and effects on oxidative stress and neurotrophic factor.Methods 82 cases of diabetic peripheral neuropathy(DPN) patients from February 2015 to October 2016 in our hospital were selected and randomly divided into observation group and control group with 41 cases in each group.The control group was treated with mecobalamin injection, the observation group were treated with calcium dobesilate tablets.The course of treatment was two weeks in two groups.Results The total efficiency of the observation group (90.24%) was higher than the control group (68.29%) , the difference was statistically significant ( P<0.05 ) , patients in the observation group after the treatment of common peroneal nerve and median nerve SCV and MCV higher than the control group, the difference was statistically significant (P <0.05), the level of serum malondialdehyde (MDA) in the observation group was lower than that in the control group and the level of superoxide dismutase ( SOD) in the observation group was higher than that in the control group, the difference was statistically significant (P<0.05), the levels of serum NGF and BDNF in the observation group were higher than those in the control group, the difference was statistically significant (P<0.05), the two groups were no obvious adverse reactions.Conclusion Calcium dobesilate tablets and mecobalamin injection curative effect in the treatment of diabetic peripheral neuropathy , and patients could improve oxidative stress and neurotrophic factors, and the safety is good, has the important research significance.%目的 探讨羟苯磺酸钙片联合甲钴胺注射液治疗糖尿病周围神经病变疗效及对氧化应激和神经营养因子的影响.方法 选取浙江省临海市第二人民医院于2015年2月~2016年10月期间收治的糖尿病周围神经病变(DPN)患者82例,按照随机数字表法分为观察组与对照组,每组各41例.对照组患者采用甲钴胺注射液治疗,观察组患者采用羟苯磺酸钙片治疗.2组疗程均为2 w.结果 观察组治疗总有效率(90.24%)高于对照组(68.29%),差异有统计学意义(P<0.05);观察组患者治疗后腓总神经和正中神经的感觉传导速度(SCV)和运动传导速度(MCV)高于对照组,差异有统计学意义(P<0.05);观察组患者治疗后血清丙二醛(MDA)水平低于对照组而超氧化物歧化酶(SOD)水平高于对照组,差异有统计学意义(P<0.05);观察组患者治疗后血清神经生长因子(NGF)和脑源性神经营养因子(BDNF)水平高于对照组,差异有统计学意义(P<0.05);2组均未发生明显不良反应.结论 羟苯磺酸钙片联合甲钴胺注射液治疗糖尿病周围神经病变疗效明显,且可改善患者氧化应激和神经营养因子,且用药安全性良好,具有重要研究意义.