益生菌制剂在老年重症肺部感染中对抗生素相关性腹泻的临床疗效

摘要

Objective To observe clinical efficacy of probiotics agents in the prevention and treatment of severe pulmonary infection in elderly patients with antibiotic-associated diarrhea (AAD).Methods 60 cases of elderly patients with severe pulmonary infection (more than or equal to 60 years old) were randomly divided into the treatment group ( 31 cases ) and control group ( 29 cases ) , the control group received broad-spectrum antibiotics or using two linked above anti-infection treatment, the treatment group were added with probiotic agent ( lactobacillus complex capsules).The diarrhea, the use of antibiotics and the stool routine, bacteria before and after 5, 10, 15 days of group were observed.Results After 15 days treatment, the number of Escherichia coli in treatment group was lower than that in control group (P<0.05), the number of Bacterium lacticum and Bifidobacterium bifidum in treatment group were higher than those in control group ( P<0.05 ) .The AAD rate in treatment goup was 12.90%, which was lower than 41.38% in control group (P<0.05).There were significant differences in beginning time and duration of diarrhea between two groups (P<0.05). Conclusion The intestinal probiotics reduced induced by antibiotics in elderly patients with severe pulmonary infection , the probiotics agents could redress intestinal flora imbalance, keep the steady state of intestinal flora, and prevent and cure the antibiotic-associated diarrhea.%目的 观察益生菌制剂在预防和治疗老年重症肺部感染中抗生素相关性腹泻(antibiotic-associated diarrhea,AAD)的临床疗效.方法 选取≥60岁的60例老年肺部感染患者,随机分为治疗组(31例)与对照组(29例),均使用广谱抗生素抗感染治疗,治疗组加用益生菌制剂(复合乳酸杆菌).观察和分析2组患者发生腹泻的情况,及使用抗生素前及使用后第5、10、15 d大便常规、菌群状况.结果 治疗后15 d,治疗组大肠杆菌显著低于对照组(P<0.05),治疗组乳酸杆菌、双歧杆菌显著高于对照组(P<0.05).治疗组AAD发生率为12.90%,显著低于对照组的41.38%(P<0.05),2组出现腹泻的时间与腹泻持续天数差异显著(P<0.05).结论 在使用抗生素的老年肺部感染患者中,肠道内的有益菌均有不同程度的减少,而益生菌的应用,可纠正肠道菌群失调,有效保持肠道菌群稳态,进而预防和治疗抗生素相关性腹泻.