丹红通精方联合左氧氟沙星对慢性前列腺炎患者血清细胞因子的影响及疗效

摘要

Objective To investigate the effect of Danhongtongjing formula combined with levofloxacin on serum cytokines in patients with chronic prostatitis. Methods 74 cases of patients with chronic prostatitis from May 2014 to April 2016 in our hospital were selected,and randomly divided into two groups,37 cases in each groups.The control group treated with levofloxacin,the observation group were treated with Danhongtongjing formula The observation group on the based of control group.The clinical symptoms,TCM syndrome and the changes of SIgA,VCAM-1 and serum VCAM-1 in prostatic fluid of two groups were compared. Results The total effective rate was 94.59% in the observation group and 78.38%in the control group,the difference was statistically significant (P<0.05).After treatment,the NIH-CPSI index of the two groups was significantly decreased,and the observation group was lower than the control group,the difference was statistically significant (P<0.05);the TCM syndrome score of both groups decreased,and the observation group was lower than the control group,the difference was statistically significant (P<0.05).The total effective rate of TCM Syndrome in observation group was 91.89%,which was significantly higher than that of the control group 72.97%,the difference was statistically significant (P<0.05).After treatment,the levels of SIgA,VCAM-1 and serum VCAM-1 in prostatic fluid were decreased,and the observation group was lower than the control group,the difference was statistically significant (P<0.05). Conclusion Danhongtongjing formula combined with levofloxacin in the treatment of chronic prostatitis patients with significant effect,can effectively regulate serum cytokines, control inflammation, improve the treatment efficiency.%目的 探讨丹红通精方联合左氧氟沙星对慢性前列腺炎患者血清细胞因子的影响及疗效.方法 选取浙江省杭州市西溪医院2014年5月~2016年4月接诊的慢性前列腺炎患者74例,随机分成2组,各37例.对照组给予左氧氟沙星治疗,观察组在对照组基础上给予丹红通精方,比较2组患者临床症状、中医症候及前列腺液中分泌型免疫球蛋白A(secretory immunoglobulin A,SIgA)、血管细胞粘附分子-1(vascular cell adhesion molecule-1,VCAM-1)及血清VCAM-1变化.结果 观察组总有效率94.59%高于对照组78.38%,差异具有统计学意义(P<0.05).治疗后,2组NIH-CPSI指数显著降低,且观察组低于对照组,差异具有统计学意义(P<0.05);2组中医证候积分均降低,且观察组显著低于对照组,差异具有统计学意义(P<0.05).观察组中医证候疗效总有效率91.89%显著高于对照组总有效率72.97%,差异具有统计学意义(P<0.05).治疗后,2组前列腺液中SIgA、VCAM-1及血清VCAM-1水平均降低,且观察组显著低于对照组,差异具有统计学意义(P<0.05).结论 丹红通精方联合左氧氟沙星治疗慢性前列腺炎患者效果显著,能有效调节血清细胞因子,控制炎症,提高治疗有效率.