Researches on efficacy of levofloxacin combined with chemotherapy in the treatment of retreated smear positive pulmonary tuberculosis and its influence on T-cell subgroup levels in peripheral blood of patients

摘要

Objective:To discuss the efficacy of levofloxacin combined with chemotherapy in the treatment of retreated smear positive pulmonary tuberculosis and its influence on t-cell subgroup levels in peripheral blood of patients. Methods:A total of 85 cases with TB were divided into control group (n=42) and study group (n=43) based on therapeutic methods, and patients in control group were given 3HRZE/6HRE conventional chemotherapy treatment, while patients in study group were added with levofloxacin treatment, on the basis of control group. Finally the influence of these two therapeutic methods on t-cell subgroup levels in peripheral blood of patients was compared. Results:(1) After treatment, t-cell subgroup levels in peripheral blood of patients in study group were significantly higher than that in control group;CD4+/CD8+level difference of patients in both groups had no statistical significance before and after treatment;(2) Adverse reaction occurrence rate of patients in control group during the therapeutic process was 14.29%(6/42), while adverse reaction occurrence rate of patients in study group during the therapeutic process was 11.63%(5/43), adverse reaction occurrence rate difference of patients during the therapeutic process in both groups had no statistical significance. Conclusion:Efficacy of levofloxacin combined with chemotherapy in the treatment of retreated smear positive pulmonary tuberculosis was obvious, and it could improve the organism immune function through improving t-cell subgroup levels in peripheral blood of patients, which was deserved clinical popularization.