芪苈强心胶囊治疗难治性心力衰竭的临床观察

摘要

目的:观察芪苈强心胶囊治疗慢性难治性心力衰竭的临床效果和对患者生活质量的影响.方法:80例慢性心力衰竭患者分为对照组A组(n=40)和治疗组B组(n=40),所有患者根据心衰治疗指南给予常规的抗心衰治疗,治疗组在此基础上给予芪苈强心胶囊治疗,随访3个月观察患者心力衰竭症状和体征的改变；心力衰竭好转的时间、住院时间、出院后1周内再住院率；电解质紊乱；超声心动图；6min步行距离试验(6MWT)；明尼苏达心衰生活质量(MLWHF).结果:2组总有效率A组为87.5％(35/40),B组为92.5％ (37/40)差异无统计学意义(P＞0.05).但B组心衰改善的时间、住院时间比A组明显减少(P均＜0.01).2组治疗水肿均有效,与治疗前比较差异有统计学意义(P均＜0.01),2组治疗后1月、2月、3月水肿积分均值比较差异有统计学意义(P均＜0.05),说明B组水肿控制更好.A组治疗期间电解质紊乱发生,74％ (37/50),B组44％ (22/50),2组比较差异有统计学意义(P＜0.01).2组均显著减少心衰患者左室舒张末期内径和提高左室射血分数(P＜0.01),B组优于A组(P＜0.05).与治疗前比较,2组均能改善患者的生活质量(P＜0.01).结论:芪苈强心胶囊治疗慢性难治性心力衰竭效果确切,能明显改善心衰患者的生活质量.%Objective:The Observation is about of clinical effect and the influence on the quality of life in treatment of patients with chronic refractory heart failure by Qiliqiangxin capsule Methods 80 cases of chronic heart failure patients were divided into control group A (n =forty) and treatment group B (n =forty),all patients according to heart failure treatment guidelines to conventional resistance to heart failure treatment,the treatment group on the basis of the given Qiliqiangxin capsule treatment,follow-up of 3 months,the patients were observed change of heart failure symptoms and signs ; Heart failure better time,length of hospital stay,1 weeks after discharge to hospital admission rates; Electrolyte disorder; Echocardiography; 6 min walking distance test (6 MWT) ; Minnesota heart failure quality of life (MLWHF).Results:Two groups of the total effective rate in group A was 87.5％ (35/40),group B was 92.5％ (37/40),there was no significant difference (P ＞ 0.05).But the group B to improve heart failure time,length of hospital stay than group A significantly reduced (P ＜ 0.01).Two groups of treatment edema are effective,and before treatment is a highly significant difference (P ＜0.01),the two groups after treatment on 1 month,2 months,3 months edema integral mean value is significant difference (P ＜ 0.05),which indicate that the better control group B edema.A group of electrolyte disorder during treatment rate was 74％ (37/50),group B 44％ (22/50),comparison of two groups difference highly significant (P ＜0.01).Two groups were significantly reduce heart failure patients with left ventricular end-diastolic diameter and improve left ventricular ejection fraction (P ＜ 0.01),group B is better than that of group A (P ＜ 0.05).Compared with before treatment,two groups of all can improve the quality of life of the patients (P ＜ 0.01).Conclusion The quality of life of heart failure was significantly improved in the treatment of patients with chronic refractory heart failure by Qiliqiangxin capsule.