药物代谢酶细胞色素P450 2D6的遗传多态性研究进展

摘要

CYP2D6是肝脏中重要的药物代谢酶,其代谢的药物占临床应用药物的20%～25%.其遗传多态性对依赖CYP2D6代谢的药物具有重要的影响.本文综述了CYP2D6在遗传多态性方面的研究进展及其临床意义.%Cytochrome P450 2D6 (CYP2D6) is an important microsome enzyme in liver which metabolizes about 20%～25% of drugs used in clinic. And these substrates of CYP2D6 are affected intensively by its genetic polymorphism. In the present article, genetic polymorphism of CYP2D6 and its clinical implications were reviewed.