Evaluation method for predicting pharmacokinetics of PM using PM liver cells of drug metabolozing enzyme cytochrome P450 having a genetic polymorphism

摘要

There is provided a novel evaluation method for predicting the pharmacokinetics of PM using PM liver cells of drug metabolizing enzyme cytochrome P450 having a genetic polymorphism. According to the present invention, the pharmacokinetics (metabolism) of PM can be predicted by using PM liver cells of CYP2D6among drug metabolizing enzyme cytochrome P450 known to have a genetic polymorphism.