Effect of genetic polymorphisms on the interplay of P-glycoprotein transporter and cytochrome P450 enzymes: Pharmacokinetics of risperidone

摘要

Inter-individual variability in oral drug efficacy and toxicity is commonly observed in all therapeutic areas.Importantly,interindividual variability in drug uptake and metabolism can result in poor drug response,adverse drug reactions,or unfavorable drug–drug interaction.One of the common causes of individual variations in drug response is genetic variation of drug transporters and metabolizing enzymes[1,2].We focus on the interplay between efflux transporter(ATP-binding cassette,subfamily B(MDR/TAP),member 1/ABCB1)and cytochrome P450s according to genetic polymorphism[3].The objective of this lecture is to investigate the combined influence of genetic polymorphisms in ABCB1 and CYP2D6 genes on risperidone pharmacokinetics[4].