一氧化氮及其对营养物质代谢的调节

摘要

Nitric oxide (NO), a major cellular signaling molecule, is produced by NO synthases (NOS) using arginine as a substrate. NO is not only a key endothelial derivative factor, but also plays an important role in the regulation of nutrient metabolism, such as glucose, fat, and amino acid. The synthetic rate of NO in cells can be regulated by arginine availability and NOS cofactors. Therefore, we can adjust the nutrient metabolism through the regulation of nitric oxide synthesis. [ Chinese Journal of Animal Nutrition, 2011, 23 ( 6 ):893-900 ]%一氧化氮是由一氧化氮合成酶以精氨酸为底物合成的重要细胞信号分子,不仅是脉管系统中重要的内皮衍生因子,而且在营养物质代谢调控上有着重要的作用.一氧化氮参与葡萄糖、脂肪、氨基酸等营养物质的代谢调控.细胞中一氧化氮的合成速率可通过各种途径控制精氨酸的有效性及一氧化氮合成酶的辅助因子来调节,通过调节一氧化氮的合成可以调节营养物质的代谢.