This experiment was conducted to study the effects of alanyl-glutamine ( Ala-Gln) dipeptide ongrowth performance. small intestinal morphology and serum biochemical indices of suckling piglets. Thepurpose was to explore the possible mechanisms of improving the health and growth potential of sucklingpiglets. Eighty-six l4-days-old piglets were from eight healthy pure Saba sows in Yunnan whose bodyweight, parity, litter size and milk yield were close to each other. One litter was a unit, and the piglets ineight litters were divided into two groups by a completely randomized design, and each group had four lit-ters. The suckling piglets in control group were fed with a basal diet. The suckling piglets in test group werefed with an experimental diet ( the basal diet +0. 3% Ala-Gln dipeptide) . The duration of the experimentwas 21 d. The results showed as follows: l) Ala-Gln dipeptide was added to the diet of suckling piglets,which significantly increased the average weanling weight of piglets aged 35 days ( P ＜0. 05) , and the average daily gain and the average daily feed intake during the whole period ( 14 to 35 d) by 17. 25％ and 31. 66％ ( P ＜ 0. 01 ) , while significantly decreased the diarrhea rate in every week during the whole period ( P ＜0. 05 or P ＜0. 01 ) . 2 ) At the age of 28 d, duodenal villus height in the test group was significantly higher than that in the control group ( P ＜ 0. 05) , and crypt depth was significantly lower than that in the control group (P ＜ 0. 05) ; jejunal villus height in the test group was significantly higher than that in the control group ( P＜ 0. 05) ; there was no difference in villus height and crypt depth in the ileum between the test group and the control group ( P ＞ 0. 05) . 3) Exogenous Ala-Gln dipeptide was added to the diet of suckling piglets, which significantly decreased serum urea nitrogen content ( P ＜ 0. 05 ) , while increased alanine aminotransferase ( P ＜ 0. 01 ) and alkaline phosphatase activities ( P ＜ 0. 05 ) in serum, and total disaccharidase activity ( P ＜0. 01 ) in jejunal mucosa of piglets aged 28 days. Ala-Gln dipeptide had no significant effects on the contents of total protein, albumin, glucose and creatinine, and the activities of lactate dehydrogenase, creatine kinase and Na+ -K+ -ATPase in serum ( P ＞ 0. 05 ) . These results indicate that supplementation of Ala-Gln dipeptide can improve the structure and function of small intestine, and the growth potential of suckling piglets. [ Chinese Journal of Animal Nutrition ,2011 ,23 ( 1 ) :94 -101 ]%本试验旨在通过研究丙氨酰谷氨酰胺(Ala-Gln)二肽对哺乳仔猪生长性能、小肠形态学、血清生化指标的影响,以探讨Ala-Gln二肽提高哺乳仔猪健康和改善生长潜力的可能机制.选用体重、胎次、产仔数、泌乳量接近的8头健康云南纯种撒坝母猪所产的14日龄仔猪86头为试验对象,以窝为单位,将8窝仔猪随机分为2组,每组4窝,对照组42头补饲基础饲粮,试验组44头补饲试验饲粮(基础饲粮+0.3%Ala-G1n二肽).试验期为21 d.结果表明:1)在哺乳期仔猪饲粮中添加Ala-Gln二肽,显著提高了35日龄仔猪断奶平均体重(P＜0.05),极显著提高了14～35日龄仔猪平均日增重17.25%、平均日采食量31. 66%(P＜0.01);试验组在试验期间各周的腹泻率均显著或极显著低于对照组(P＜0.05或P＜0.01).2)试验组28日龄仔猪十二指肠绒毛高度显著高于对照组(P＜0.05),隐窝深度显著低于对照组(P＜0.05);空肠绒毛高度显著高于对照组(P＜0.05);在回肠上,试验组与对照组无显著差异(P＞0.05).3)添加外源Ala-Gln二肽显著降低了28日龄仔猪血清尿素氮含量,极显著或显著提高了血清谷丙转氨酶(P＜0.01)、碱性磷酸酶活性(P＜0.05),极显著提高了空肠黏膜总二糖酶活性(P＜0.01),对总蛋白、白蛋白、葡萄糖、肌酐含量,乳酸脱氢酶、肌酸激酶、Na+-K+-ATP酶活性均无显著影响(P＞0.05).结果提示:在哺乳仔猪补料中添加外源性Ala-Gln二肽,可改善仔猪早期肠道结构与功能,提高生长潜力.
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