抗菌肽抑制脂多糖诱导的炎症反应

摘要

Antimicrobial peptides ( AMPs) are a kind of small molecular polypeptide which show the specific antibacterial mechanism to multiple drug⁃resistant strains. In addition, with anti⁃inflammatory activity, AMPs relieve inflammation by directly neutralizing lipopolysaccharide ( LPS) and inhibiting the release of biological inflammatory factors. Meanwhile, they also affect the acquired immunity through the chemotaxis of leukocytes and promoting the proliferation of the immune cells to adjust the host immune system and play a protective role. This essay summarized the mechanism of LPS induced inflammation and the AMPs to inhibit LPS induced in⁃flammation in recent years.%抗菌肽是一种对多重耐药菌株表现出特异性抗菌机制的小分子多肽。同时，抗菌肽还具有抗炎活性，可以通过直接中和脂多糖（ LPS）、抑制生物性炎症因子的产生来减轻炎症反应；亦可通过趋化白细胞、促进免疫细胞增殖等来影响获得性免疫，从而调节宿主免疫系统发挥保护作用。本文综述了近年来LPS诱导炎症产生的机制及抗菌肽抑制LPS诱导炎症反应的作用机理。