中国不同年龄发病原发性干燥综合征的临床特征

摘要

Objective To compare the clinical and laboratory characteristics of patients with primary Sjogren' s syndrome ( pSS) with different age of onset. Methods From January 2009 to November 2011, pSS patients from 16 clinical centers in China were collected. The patients were divided into three groups according to their age of onset. T-test, nonparametric test and Chi-square test were applied to compare data in subgroups. Results The peak age of onset of pSS was 40 -49 (32. 3% ) , secondly were 50 ~ 59 (24. 9% ) , 30 -39 (21. 3% ) , <30 (10. 8% ) and≥60 (10. 8% ). Compared with the patients with the age of onset 30 - 59, patients with age of onset < 30 had lower incidence of arthritis and interstitial lung disease (P <0. 05). Compared with the patients with age of onset 30 -59, patients with age of onset ≥60 had less female patients (P <0. 05) , the time cost for diagnosis was shorter (P < 0. 05 ) , the incidence of dry mouth and interstitial lung disease were higher ( P < 0. 05 ) , and incidence of recurrent parotid enlargement and decreased blood WBC were lower(P <0. 05) , the positive rates of anti SSA antibody and anti SSB antibody were lower(P <0. 05). Compared with the patients with age of onset < 30, patients with age of onset≥ 60 had higher incidence of dry mouth (P <0. 05) , liver function abnormal (P < 0. 05) and interstitial lung disease(P <0. 05) , and lower positive rates of decreased blood WBC , anti SSA antibodyand anti SSB antibody ( P < 0. 05 ) . Conclusions With the growth of age, The positive rates of liver involvement, interstitial lung disease and arthritis were growing higher, while blood system involvement, and the positive rates of anti SSA antibody and anti SSB antibody were getting lower.%目的 探讨我国不同年龄发病的原发性干燥综合征(primary sj(o)gren's syndrome,pSS)患者临床特征及实验室指标的异同.方法 现况调查2009年1月至2011年11月于我国16家临床中心诊治、符合2002年pSS国际分类(诊断)标准的患者,据发病年龄<30岁,30~59岁,≥60岁将患者分为3组,并采用独立样本t检验、非参数检验、x2检验对不同年龄发病的pSS患者行组间对比.结果 pSS患者发病高峰期在40~49岁(32.3%),其次是50~59岁(24.9%)及30~39岁(21.3%),<30岁发病组及≥60岁发病组均占10.8%.与30～59岁发病组相比,<30岁发病组关节炎、间质性肺炎发病率低,差异有统计学意义(P<0.05).与30～59岁发病组相比,≥60岁发病组女性比例低(P<0.05),出现症状至明确诊断的时间间隔短(P<0.05),口干发病率高(P<0.05),反复腮腺肿大出现率低(P<0.05),血白细胞计数降低比例低(P<0.05),间质性肺病发病率高(P<0.05),抗SSA、SSB抗体阳性率低(P<0.05).与<30岁发病组比较,≥60岁发病组口干发病率高(P<0.05),血白细胞计数降低比例低(P<0.05),肝脏受累、间质性肺病发病率高(P<0.05),抗SSA、SSB抗体阳性率低(P<0.05).结论 随发病年龄增长,pSS患者肝脏受累、间质性肺病、关节炎的发生率增高,血白细胞计数降低、抗SSA抗体及抗SSB抗体阳性率则呈下降趋势.