Objective To evaluate the efficacy and safety about Metacycline combining 0.025％ Tretinoin Cream to treat acne vulgaris. Methods 116 acne vulgaris' patients were incorporated into two groups: treatment group and matched group. Group A: 59 patients were taken orally Metacycline capsules 0.3, twice a day. Group B: 57 patients were taken orally Metronidazole tablets 0.2, three times a day. Both groups were used 0.025％ Tretinoin Cream before sleep for use external, once a day. The course of treatment: 4 weeks. Results The care rate: Group A 62.7％,Group B 28.1％.The effective rate: Group A 94.9％ ,Group B 71.9％ .The comparative differences between the two groups' care rate and effective rate have statistical significance (x2=2.48,P＜0.01). Conclusion Metacycline is a very good antibiotic to treat the acne vulgaris. This treatment is efficacious and safe.%目的:评价美他环素联合0.025%维A酸乳膏治疗中度寻常性痤疮的疗效与安全性.方法:将116例寻常性痤疮患者随机分为治疗组和对照组,治疗组59例,口服美他环素胶囊0.3g,2次/天;对照组57例,口服甲硝唑片0.2g,3次/天;两组均于睡前外用0.025%维A酸乳膏,每天1次,疗程4周.结果:治疗组痊愈率为62.7%,有效率94.9%;对照组分别为28.1%,71.9%;两组痊愈率和有效率比较差异均有统计学意义(x2=2.48,2.77,P＜0.01).结论:美他环素联合0.025%维A酸乳膏治疗中度寻常性痤疮疗效确切,安全性高.
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