Objective To investigate the effect of topical resveratrol on skin erythema induced by solar simulator ultraviolet irradiation. Methods Twenty volunteers were recruited and 6 experimental sites were separately marked on their bilateral backs. Sites 1 to 4 were topically applied with resveratrol combination with antioxidant, antioxidant, resveratrol, base, respectively. The products were applied to left-side followed by irradiation, and the products were applied to right-side after irradiation. Sites 5 and site 6 were separatedly designated as positive control and negative control sites. The irradiation last 4 days and skin erythema was observed. Results On the 1st and 2nd days after irradiation, no or only slight erythema were observed on site 1 to site 3. On the 3rd and 4th days, the erythema of site 1 and site 3 remained unchanged comparing to that on the 2nd day, whereas the erythema of site 2 became obvious than before and lighter than that of site 5. The erythema on left-side is slighter than that on right-side. Conclusion Topical resveratol could effectively prevent (more obviously) and reverse the skin erythema induced by solar simulator ultraviolet irradiation.%目的:观察白藜芦醇外涂对模拟日光照射皮肤红斑的影响.方法:将20名志愿者左右侧背部分别划出6个部位.部位1～4分别涂抹白藜芦醇+抗氧化剂、抗氧化剂、白藜芦醇、基质,左侧先涂抹后照光,右侧先照光后涂抹;部位5、6分别为阳性及阴性对照.连续4天,观察皮肤红斑.结果:照光后第1、2天,部位1～3无或隐约可见淡红斑；第3、4天,部位1、3红斑较第2天无加深,部位2红斑加深但较部位5轻.左侧形成的红斑较右侧相应部位轻.结论:白藜芦醇外用可有效预防与治疗模拟日光照射诱导的皮肤红斑,尤以预防性应用效果更好.
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