Objective To explore the relationship between index of insulin resistance and different kinds of metabolic disorders among rural residents in Yanbian area. Methods A total of 1235 adult subjects from 2 villages in Antu county, Yanbian were enrolled with their anthropometric and hiochemical indices obtained. Degrees of insulin resistance ( IR ) were estimated using the homeostasis model assessment ( HOMA ) method. Metabolis syndrome ( MS ) was diagnosed using the guidelines of "Prevention and Treatment of Blood Lipid Abnormality in Chinese Adult". Results Logistic regression analysis showed that the prevalence of MS increased significantly along with the increase of HOMA - IR after adjustment for sex. race, age , smoking, drinking and other components of MS in model 1 ( P = 0.000 ); OR values increased in the IR group and were 6.774 for central obesity , 6.544 for hyperglycemia, 2.397 for low HDL - C, 2.353 for high TG and 2.035 for hypertension, respectively. After adjustment for the same set of variables as in model 1 as well as for general obesity in model 2, OR values in the IR group turned out to be 6.549 ( hyperglycemia ), 3.221 ( central obesity ), 2.349 ( high TG ), 2.191 ( low HDL - C ) and 1.879 ( hypertension), with the risk increased with HOMA - IR ( P＜0.05 ) . Risk of general obesity increased with HOMA -IR ( P =0.000 ),with an OR value of 4.140 in the IR group. Risk of MS increased with HOMA -IR ( P =0.000 ), with an OR value of 4.703 in the IR group. Levels of HOMA - IR were significantly higher among subjects with MS than without ( F =59.013, P = 0.000 ) and increased along with the increment of MS component number ( F = 43.903, P =0.000 ) . Conclusion The current observation shows that levels of HOMA - IR are strongly associated with the prevalence of MS and all its components, as well as general obesity. However different degrees of impact are displayed among different metabolic disorders. HOMA - IR level increases with the increment of MS component number.%目的 探讨胰岛素抵抗指数分布特征及其与多种代谢异常的相关性.方法 以延边朝鲜族自治州安图县2个村的1 235名常住农民为研究对象.调查其体格指标,检测其血清胰岛素及代谢相关指标.采用稳态模型评估法(HOMA)估测人体胰岛素抵抗(IR)程度,根据<中国成人血脂异常防治指南>建议的标准诊断代谢综合征(MS).结果 多元Logistic回归分析结果表明,模型1:调整性别、民族、年龄、文化程度、吸烟、饮酒及MS其他各组分,MS各组分的患病危险均随胰岛素抵抗指数(HOMA-IR)的增加而升高(P均=0.000),而且IR组MS各组分的患病危险明显升高,其OR值依次为6.774(腹型肥胖)、6.544(高血糖)、2.397(低高密度脂蛋白胆固醇血症)、2.353(高三酰甘油血症)及2.035(高血压);模型2:调整模型1中的变量和整体肥胖,IR组MS各组分OR值依次为6.549(高血糖)、3.221(腹部肥胖)、2.349(高三酰甘油血症)、2.191(低高密度脂蛋白胆固醇血症)及1.879(高血压),而且其患病危险均随HOMA-IR的增加而升高(P＜0.05).整体肥胖的患病危险随HOMA-IR的增高而呈升高趋势(P=0.000),IR组OR=4.140.随着HOMA-IR的增加,MS患病危险性明显升高(P=0.000),IR组OR=4.703.协方差分析结果表明,MS组和无MS组HOMA-IR比较差异有统计学意义(F=59.013,P=0.000);且随着MS组分数目的 增加,HOMA-IR呈升高趋势(F=43.903,P=0.000).结论 本地区成人HOMA-IR与MS及其各组分、整体肥胖患病显著相关,但其对不同代谢异常的影响程度有所不同;随着MS组分数目的 增加,HOMA-IR水平呈升高趋势.
展开▼
