DOES LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 LEVELCORRELATE WITH INSULIN RESISTANCE STATES IN METABOLICSYNDROME, AN EARLY ATHEROSCLEROTIC PHASE?

摘要

Background. Lipoprotein-associated phospholipase A2 is a novel inflammation marker that generates pro-inflammatory molecules from oxidized LDL.Aim. We aimed to investigate its role in individuals with insulin resistance and metabolic syndrome which is representative of early stages of atherosclerosis.Methods. We evaluated 114 subjects with metabolic syndrome in a cross-sectional pattern. Waist circumference was measured. Fasting plasma glucose, total cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-C), LDL-cholesterol (LDL-C), fasting insulin were measured by standard assays. Oral glucose tolerance test was applied to patients with fasting blood glucose < 126 mg/dL. Patients were classified to tertiles according to their insulin resistance states. Lp-PLA2 mass levels were measured.Results. There was a correlation between hypertension and HOMA tertiles; HDL-C, hypertriglyceridemia, hyperglycemia were not correlated with HOMA tertiles (p = 0.024, p=0.66, p=0.66, p = 0.18, respectively). We cannot find any association between HOMA tertiles and Lp-PLA2 levels. Triglyceride was negatively correlated with Lp-PLA2.Conclusion. Lp-PLA2 is not correlated with insulin resistance in subjects with metabolic syndrome.