Insulin Resistance is Associated with Urinary Formaldehyde Levels in the Elderly

摘要

Background Endogenous formaldehyde(FA) was reported to be involved in age-related disease such as cardiovascular disease. Aims The aim of this study was to investigate the relation of urinary FA with insulin resistance in the elderly. Methods We used data from the Korean Elderly Environment Panel (KEEP) Study. It recruited 560 Koreans 60 yrs old or more in Seoul from Aug. 2008 to Aug. 2010. Urinary FA, glucose, insulin, homeostatic model assessment-insulin resistance (HOMA-IR), malondialdehyde(MDA) were measured repeatedly up to 3 times. Results Urinary FA levels were significantly associated with HOMA-IR after adjustment for confounders (β: 0.5394, p ＜0.0001). They were also significantly associated with insulin (β: 1.4562, p ＜0.0001), and MDA (β: 0.2568, p ＜0.0001). Urinary FA levels upper than median had a 1.51-fold (95 % CI: 1.02-2.23) increased risk of insulin resistance (HOMA ≥ 2.5) compared to those lower than median. Conclusions The findings of this study suggest that endogenous FA increases insulin resistance in the elderly. Oxidative stress contributed by FA might play a role in a mechanism of insulin resistance.