多西他赛联合卡铂同步放化疗门诊治疗中晚期宫颈癌的近期疗效观察

摘要

目的 观察多西他赛联合卡铂同步放化疗门诊治疗中晚期宫颈癌患者的近期疗效及毒副作用.方法 选择81例中晚期宫颈癌患者,给予多西他赛75 mg/m2+卡铂300 mg/m2,静脉滴注,21 d为1个周期.所有患者完成3~4个周期化疗;同步行宫颈放疗(体外照射加192Ir腔内照射).观察治疗的近期疗效及毒副作用.结果 81例患者中完全缓解79例、部分缓解2例、稳定0例、进展0例,有效率100.0%.主要毒副作用为胃肠道反应、骨髓抑制、放射性肠炎、放射性膀胱炎,其发生率分别为58.0%、40.7%、16.0%、11.1%.无放化疗相关死亡病例.结论 多西他赛联合卡铂同步放化疗治疗中晚期宫颈癌,近期疗效确切、耐受性好,可用于门诊治疗.%Objective To analyze the efficacy and side effects of docetaxel combined with carboplatin in concurrent chemoradiotherapy of advanced cervical cancer.Methods Eighty-one patients received docetaxel (75 mg/m) combined with carboplatin (300 mg/m), iv gtt, 21 days/a cycle.Every patient received 3 or 4 cycles of chemotherapy, combined with synchronous radiotherapy (external irradiation Combined with Ir afterload intracavitacy radiating).The short-term effect and side effects were analyzed.Results A complete response (CR) was seen in 79 patients, partial response (PR) in 2, stable disease (SD) in 0 and progression disease (PD) in 0.The response rate (RR) was 100.0% .The most frequent side effects were gastrointestinal toxicity, hematologic suppression , radiation enteritis and cystitis, with the incidence of 58.0% , 40.7% , 16.0%, 11.1%, respectively.No treatment-related death occurred.Conclusion The combination of docetaxel and carboplatin appears to be effective, safe and tolerable for patients in concurrent chemoradiotherapy in outpatient clinic.