Objective To compare the effects of weight loss by dieting and aerobic exercise on the improvement of nonalcoholic fatty liver disease.Methods Obese individuals〔n=30,BMI ranged from 26 to 35 kg/m2,with an average of (31.8±1.6) kg/m2〕 with clinically confirmed nonalcoholic fatty liver disease (NAFLD) admitted in Department of Gastroenterology,the Affiliated Puai Hospital of Tongji Medical College,Huazhong University of Science and Technology from May 2013 to May 2015 were recruited.They were divided into weight loss group (group A,n=15) and aerobic exercise group (group B,n=15) by the random number table.The daily calorie intake for individuals in group A was about 1 500 kcal,and they did not do any aerobic exercise.The individuals in group B did supervised 150-min aerobic exercise with the heart rate value as 45%~55% of HRmax,3 times a week,for 4 weeks without changing the eating habits and increasing the nutrient intake.Comparisons were made between the groups in terms of the ALT,fasting plasma glucose(FPG),free fatty acid (FFA),fasting insulin(INS),and homeostasis model assessment of insulin resistance (HOMA-IR) and visceral adipose tissue (VAT) area before and after the intervention.Results The distribution of gender and age was similar in both groups(P>0.05).Before and after the intervention,the weight and BMI did not differ significantly between the groups (P>0.05).Before intervention,two groups had no significant differences in the ALT,FPG,FFA,INS and HOMA-IR (P>0.05);after intervention,ALT,FPG,INS and HOMA-IR of two groups were still similar,but the FFA in group B was substantially lower than that in group A(P<0.05).No notable differences in the VAT area were found between the groups before intervention(P>0.05);however,after intervention,group B had much smaller VAT area than group A(P<0.05).Conclusion Compared with weight loss by dieting,aerobic exercise is more effective for NAFLD.%目的 比较节食减重与有氧运动分别对非酒精性脂肪肝(NAFLD)患者的改善作用.方法 选取2013年5月-2015年5月在华中科技大学同济医学院附属普爱医院消化内科门诊及住院部确诊为NAFLD的患者30例,BMI 26~35 kg/m2,平均BMI(31.8±1.6)kg/m2.采用随机数字表法将所有患者分为A组和B组,每组15例.A组患者采用节食减重治疗,保证每天的饮食热量控制在1 500 kcal,不进行任何有氧运动.B组患者采用有氧运动治疗,每周运动3次,每次运动心率控制在最大心率(HRmax)的45%~55%,每周运动时间为150 min,同时保持既有饮食习惯,不因为运动额外增加饮食,共运动4周.比较两组干预前后ALT、空腹血糖(FPG)、血非酯化脂肪酸(FFA)、空腹胰岛素(INS)水平及胰岛素抵抗指数(HOMA-IR)、内脏脂肪组织(VAT)面积.结果 两组性别、年龄比较,差异无统计学意义(P>0.05);两组干预前后体质量、BMI比较,差异均无统计学意义(P>0.05).两组干预前ALT、FPG、FFA、INS水平及HOMA-IR比较,差异无统计学意义(P>0.05);两组干预后ALT、FPG、INS水平及HOMA-IR比较,差异无统计学意义;B组干预后FFA水平低于A组,差异有统计学意义(P<0.05).两组干预前VAT面积比较,差异无统计学意义(P>0.05);B组干预后VAT面积小于A组,差异有统计学意义(P<0.05).结论 有氧运动比节食减重对NAFLD的改善作用更明显.
展开▼
