49株鲍曼不动杆菌的耐药性分析

摘要

Objective :To analysis resistance of 49 strains of acinetobacter baumannii for clinical control and treatment of acinetobacter baumannii provides the basis.Methods :From January 2010 to January 2011,specimens of secretions,cerebrospinal fluid,lung lavage fluid,sputum,purulent fluid in hospitalized patients were separated out of acinetobacter baumannii 49 strains,used VITEK-2 system to identify bacteria ;Drug sensitive test was conducted by antibiotics drug diffusion method ;acinetobacter baumannii resistance was analyzed by WHONET 5.4 analysis software.Results :Acinetobacter baumannii resistance had the grim situation,the separating and resistant rate were increasing year by year,and multiple resistance and the resistance ratio increased significantly.Resistance of seven clinical common antibiotic was tested in 49 strain of acinetobacter baumannii,the antibiotic resistance rate of gentamycin, meropenem,cefepime,ceftazidime,cefotaxime,ciprofloxacin,amikacin were 53.06%,32.65%,22.45%,32.65%,44.90%,30.61%,8.16%.Through the data,the antibiotic resistance rate of gentamycin was higher.Conclusion :Compound drug and active antibacterial agent are more effectively.The measures of cleaning the sanitary status in patient’s living space and improving immunity can help to control and treat acinetobacter baumannii.%　　目的：对49株鲍曼不动杆菌的耐药性进行分析，为临床控制和治疗鲍曼不动杆菌提供依据.方法：以2010年1月-2011年1月笔者所在医院的住院患者伤口分泌物、脑脊液、肺灌洗液、痰液、脓液为标本，共分离出鲍曼不动杆菌49株，应用 VITEK-32系统进行细菌鉴定；抗菌药物纸片扩散法行药敏试验；WHONET 5.4软件分析鲍曼不动杆菌的耐药性.结果：鲍曼不动杆菌耐药形势严峻，其分离率和耐药率呈逐年上升趋势，且多重耐药和泛耐药比例明显增加.49株鲍曼不动杆菌对7种临床常用抗生素的耐药性测试表现为：庆大霉素53.06%、美罗培南32.65%、头孢吡肟22.45%、头孢他啶32.65%、头孢噻肟44.90%、环丙沙星30.61%、阿米卡星8.16%.通过数据显示，其中庆大霉素耐药率最高.结论：针对鲍曼不动杆菌，复合性药物和活性抗菌剂更为有效，且在患者治疗过程中对患者生存空间的卫生状况进行维护、提升患者免疫水平等措施，都有助于鲍曼不动杆菌的控制和治疗.