大剂量甲泼尼龙联合丙种球蛋白治疗成人重症免疫性血小板减少症的疗效评价

摘要

Objective:To evaluate the effect of large dose of Methylprednisolone combined with Gamma Globulin in treatment of adult patients with immune thrombocytopenic(ITP).Method:The clinical data of 39 adult patients with ITP in our hospital from August 2012 to February 2015 were retrospectively analysed, all patients were treated with large dose of Methylprednisolone combined with Gamma Globulin,the platelet levels and the adverse reaction were observed before and after treatment, and evaluated the overall clinical efficacy.Result:After treatment,the average PLT count of the 39 patients was (124.7±19.4)×109/L,which was higher than (8.7±2.4)×109/L before treatment, the difference was statistically significant(P＜0.05), the total efficiency rate was 94.9%.During the treatment,1 cases had liver injury,after hepatoprotective drug treatment, the ALT level returned to normal. Conclusion:Taking large dose of Methylprednisolone combined with Gamma Globulin in treatment of adult patients with immune thrombocytopenic can further improve the clinical effect, and has high security, it is an ideal treatment methods.%目的:评价大剂量甲泼尼龙联合丙种球蛋白治疗成人重症免疫性血小板减少症(ITP)的疗效.方法:回顾性分析2012年8月-2015年2月笔者所在医院收治的39例成人ITP患者的临床资料,所有患者均给予大剂量甲泼尼龙联合丙种球蛋白治疗,观察治疗前后患者的血小板水平和治疗过程中的不良反应,对总体临床疗效进行评价.结果:本组39例患者治疗后的血小板(PLT)平均计数为(124.7±19.4)×109/L,明显高于治疗前的(8.7±2.4)×109/L,差异有统计学意义(P＜0.05),治疗总有效率为94.9%.治疗期间1例患者出现肝损害,给予保肝护肝药治疗后丙氨酸氨基转移酶(ALT)恢复正常.结论:大剂量甲泼尼龙联合丙种球蛋白治疗成人重症ITP能够进一步提高临床疗效,且安全性较高,是一种理想的治疗方案.