IP-10、OPN、TGF-β1在活动性肺结核患者中的诊断价值

摘要

目的：探讨血γ干扰素诱导蛋白-10(IP-10)、骨桥蛋白(OPN)、转化生长因子β1(TGF-β1)检测在活动性肺结核诊断中的意义。方法：收治活动性肺结核患者84例、健康志愿者80例，检测两组患者的血清 IP-10、OPN、TGF-β1水平，采用ROC曲线评价3者的临床应用价值。结果：活动性肺结核组的患者的IP-10、OPN、TGF-β1水平均显著高于健康志愿者组，差异有统计学意义(P＜0.05)。结论：IP-10、OPN、TGF-β1水平在活动性肺结核中显著升高，可作为活动性肺结核诊断的重要指标。IP-10是诊断活动性肺结核的最敏感指标，三者联合监测在活动性肺结核的诊断中均具有较高的特异性和灵敏度，可提高活动性肺结核的诊断率。%Objective:To investigate the serum gamma interferon inducible protein-10(IP-10),osteopontin(OPN),transformation growth factor β1(TGF-β1)detection in the diagnosis of active pulmonary tuberculosis.Methods:84 patients with active pulmonary tuberculosis and 80 cases of healthy volunteers were selected.The serum levels of IP-10,OPN,TGF-β1 were detected in the two groups.The clinical application value of the three indexes were evaluated by ROC curve.Results:The levels of IP-10,OPN and TGF-β1 in the patients with active pulmonary tuberculosis were significantly higher than those in the healthy volunteers group, and the difference was statistically significant(P<0.05).Conclusion:The levels of IP-10,OPN and TGF-β 1 were significantly increased in active pulmonary tuberculosis,which can be used as an important indicator for the diagnosis of active pulmonary tuberculosis.IP-10 is the most sensitive marker for diagnosis of active pulmonary tuberculosis.The combination of the 3 monitoring has high specificity and sensitivity in the diagnosis of active pulmonary tuberculosis,which can improve the diagnostic rate of active pulmonary tuberculosis.