小儿复方地芬诺酯中毒50例临床分析

摘要

Objective:To analyze the treatment and prevention of pediatric compound diphenoxylate poisoning.Methods:The clinical manifestations,diagnosis,auxiliary examination,laboratory data and treatment of 50 cases of children were analyzed retrospectively.Results:48 cases were rescued successfully.Because the history was not clear,2 cases were given not thoroughly repeated gastric lavage and catharsis;the head CT displayed severe cerebral edema;they appeared blindness,mental retardation and life cannot provide for themself.The electroencephalogram slowed slow wave.The naloxone treatment effect was satisfactory, but there were still serious cases.Conclusion:Early diagnosis,timely and thorough repeated gastric lavage,catharsis and application of naloxone treatment are the keys to rescue compound diphenoxylate poisoning successfully.%目的：分析小儿复方地芬诺酯中毒的救治与预防。方法：对50例患儿的临床表现、诊断、辅助检查及化验资料、治疗进行回顾性分析。结果：48例患儿均抢救成功。2例患儿由于病史不清，未彻底反复洗胃、导泻，头颅CT显示严重脑水肿，出现失明、智力障碍，生活不能自理。脑电图提示慢波。纳洛酮治疗效果满意，但仍有严重病例出现。结论：早期诊断、及时彻底反复洗胃、导泻及应用纳洛酮治疗是抢救复方地芬诺酯中毒成功的关键。