冠心病患者微量白蛋白尿与可溶性糖基化终产物受体的关系研究

摘要

Objective:To study the relationship between microalbuminuria( MAU )and soluble glycation end-product receptor( sRAGE ) levels in patients with coronary artery disease( CAD ).rnMethods: A total of 149 patients were enrolled and defined into 2 groups according to coronary angiography diagnosis as Non-CAD group,n = 50 and CAD group,n = 99. CAD group were further divided into MAU+sub-group,n = 26 and MAU—sub-group,n = 73. Plasma levels of sRAGE were examined and compared among different groups. Logistic regression analysis was performed to observe the relationship between MUA and sRAGE levels in CAD patients.rnResults: sRAGE level in CAD group( 732. 6 ± 133. 2 ) was much lower than that in Non-CAD group( 1 055. 5 ± 279. 5 ); sRAGE level in MAU+ sub-group( 655. 3±121. 4 )was much lower than that in MAU—sub-group( 760. 1±127. 0 ) ,all P<0. 001. Logistic regression analysis showed that plasma MAU level was negatively related to sRAGE,P<0. 018,95% CI 0. 992 ～0. 999.rnConclusion:MAU was significantly and negatively related to plasma sRAGE,it may work as a novel biomarker for risk predicting in CAD patients.%目的:研究冠心病患者微量白蛋白尿(MAU)与可溶性糖基化终产物受体(sRAGE)的关系.方法:纳入符合标准的149例患者,根据冠状动脉造影结果分为冠心病组(n=99)和非冠心病组(n=50);并将99例冠心病患者按照有无MAU分为冠心病MAU亚组(n=26)和冠心病非MAU亚组(n=73);比较各组间sRAGE的水平,并使用logstic回归进行分析,观察冠心病患者MAU与sRAGE的关系.结果:sRAGE各组间比较:冠心病组(732.6±133.2)明显低于非冠心病组(1055.5±279.5),冠心病MAU亚组(655.3±121.4)明显低于冠心病非MAU亚组(760.1±127.0),差异均有统计学意义(P均＜0.001).logistic回归分析显示:MAU与sRAGE明显负相关(P=0.018,95%可信区间0.992~0.999).结论:冠心病患者MAU水平与sRAGE明显负相关,sRAGE可能是预测冠心病患者风险的新型生物标志物.