To explore effect of exercise and Rosiglitazone on reducing ADMA ,is there the pres‐ence of synergistic effect ?STZ induced T 2DM rats model were divided into control group , T2DM group ,T2DM + Rosiglitazone group ,T2DM + Exercise group ,and T2DM + Rosiglita‐zone+ Exercise group ,for 10 weeks intervention .The results show that Rosiglitazone can re‐duce the level of CM L ( P< 0 .01 ) and ADM A ( P<0 .01 ) ,and increase the liver ppar‐gamma (P< 0 .01) and DDAH‐1(P< 0 .01) mRNA expression compared with T2DM group .Exer‐cise can reduce the level of CM L ( P< 0 .01 ) and ADM A ( P< 0 .05 ) ,and increase the liver ppar‐gamma(P< 0 .05) and DDAH‐1(P< 0 .01) mRNA expression compared with T2DM group .Exercise and Rosiglitazone combined together reduce the level of CML significantly low‐er than single Rosiglitazone group(P<0 .01) ,ADMA significantly lower than the single exer‐cise group(P< 0 .05) ,liver ppar‐gamma and DDAH ‐1 mRNA expression were significantly higher than exercise group(P< 0 .01) and Rosiglitazone group(P< 0 .01) separately .In con‐clusion ,there is possible synergistic effect of exercise and Rosiglitazone on reducing ADM A ,its mechanism based on AGEs/PPAR‐gamma/DDAH/ADMA pathway .%目的：研究运动与罗格列酮联合对T2DM大鼠ADMA水平的影响，观察其是否存在协同效应。方法：采用高质饮食结合腹腔注射低剂量 STZ的方法建立 T2DM 大鼠模型，将实验动物分为正常对照组、T2DM 组、T2DM＋运动组、T2DM＋罗格列酮组和 T2DM＋运动＋罗格列酮组，每组给予相应的干预10周。结果：罗格列酮可以降低 T2DM 大鼠 CML （ P＜0．01）和ADMA（P＜0．01），同时上调肝脏PPAR‐γ（P＜0．01）和DDAH‐1（P＜0．01）mR‐NA表达，而运动可以降低 T2DM 大鼠CML（P＜0．01）和ADMA（P＜0．05），同时上调肝脏PPAR‐γ（P＜0．05）和DDAH‐1（P＜0．01） mRNA表达；运动和罗格列酮联合干预组CML明显低于罗格列酮单独干预（ P＜0．01），ADMA 明显低于单独运动干预（ P＜0．05），肝脏PPAR‐γ和DDAH‐1mRNA表达分别显著高于单独运动（（ P＜0．01）和单独罗格列酮（ P＜0．01）干预。结论：运动和罗格列酮在降低 ADMA保护血管内皮方面可能存在协同效应，其机制可能是基于 AGEs／PPAR‐γ／DDAH／ADMA途径。
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