基于分子印迹技术的生物黏附给药聚合物的制备及表征

摘要

To construct novel bioadhesive drug delivery systems based on molecular imprinting technique,galactose-imprinted pol-ymers were synthesized by the bulk polymerization method.Influence of monomer type,cross-linking degree and amount of tem-plate on the adsorption capacity of imprinted polymer to mucin was investigated.The results show galactose-imprinted polymer can effectively and quickly adsorb mucin.The type of monomer,the crosslinking extent,and the amount of template molecules can significantly influenc the adsorption capacity of polymers.Galactose-imprinted polymer is of good potential for future bioadhe-sive applications.%针对黏膜特征分子黏蛋白，基于分子印迹技术，构建新型生物黏附性给药系统。采用整体聚合法，以半乳糖为模板分子，用丙烯酰类材料制备半乳糖印迹聚合物。以聚合物对黏蛋白的吸附量为指标，考察了单体材料种类、交联度、模板分子用量等因素对黏蛋白吸附量的影响，并对优选处方所得的印迹聚合物的吸附动力学进行了考察。结果表明：与非印迹聚合物相比，半乳糖印迹聚合物能够有效地吸附黏蛋白，单体材料种类、交联度、模板分子用量等因素均对聚合物的吸附能力有显著影响，吸附达到平衡较快。半乳糖印迹聚合物能够与黏蛋白发生明显的相互作用，在生物黏附给药方面具有较好潜力。