影响CXCL12/CXCR4在NSCLC中表达的相关性研究

摘要

Objective To detect the expression of CXCL12 and CXCR4 in non small cell lung cancer (NSCLC) and adjacent normal tissue, and to analyze the significance of their positive expression, and the correlation between positive expression and related NSCLC parameters. Methods Immunohistochemical staining method was applied to detect 62 cases of clinically diagnosed NSCLC and the normal lung tissue samples above 5 cm of the shortest path. Results There were statistically significant difference between the positive expression of CXCL12, CXCR4 in NSCLC and NSCLC adjacent normal tissue (P<0.05). The positive expression of CXCL12,CXCR4 in NSCLC also had statistically significant difference with TNM period of NSCLC and mediastinal lymph node metastasis (P<0.05). Conclusion The expression of CXCL12 and CXCR4 in NSCLC tissue can promote the infiltration, development and metastasis of NSCLC cancer tissue, and it is correlated with mediastinal lymph node metastasis. The expression has specificity and targeting feature.%目的：检测CXCL12、CXCR4在非小细胞肺癌(NSCLC)组织及癌旁正常肺组织中的表达情况，分析其阳性表达的意义及其阳性表达与NSCLC相关参数的联系。方法采用免疫组织化学染色方法对临床确诊的NSCLC癌组织、离其最短径5 cm以上正常肺组织标本62例进行检测。结果 NSCLC细胞CXCL12、CXCR4与NSCLC癌旁正常肺组织阳性表达率差异有统计学意义(P<0.05)；与NSCLC的TNM分期、纵隔淋巴结转移等差异有统计学意义(P<0.05)。结论 CXCL12、CXCR4在NSCLC组织中表达能够促进NSCLC癌组织的浸润、发展及转移，并且与纵隔淋巴结转移有关；其表达是专一性的，具有靶向性。