孕11~13+6周超声测量胎儿颈项透明层厚度在检出胎儿异常中的临床价值

摘要

Objective To investigate clinical value by ultrasonic measurement of fetal nuchal translucency (NT) thickness in detection of fetal abnormality during 11~13+6 gestational weeks.Methods A total of 1700 pregnant women during 11~13+6 gestational weeks received abdominal ultrasound detection in their prenatal examination. Fetal NT value was calculated and taken in follow-up.Results There were totally 28 cases with abnormalities, as 24 cases with NT value ≥3 mm (5 cases with abnormal chromosome karyotype and 19 cases with abnormal structure and normal chromosome karyotype) and 4 cases with NT value <3 mm (3 cases with abnormal structure and 1 case with abnormal chromosome karyotype). The difference of NT values in difference geatational weeks had statistical significance (P<0.05), and normal NT value had no obvious correlation with age of pregnant woman (P>0.05).Conclusion There is a close correlation between thickened NT value and fetal abnormality. Implement of ultrasonic detection for fetal NT thickness during 11~13+6 gestational weeks shows an important index in screening of fetal abnormality. This method is convenient and fast, as well as non-invasive. It is worth promoting.%目的 探讨孕11~13+6周超声测量胎儿颈项透明层(NT)厚度在检出胎儿异常中的临床价值.方法 1700例孕11~13+6周接受产前检查的孕妇接受腹部超声检测, 计算胎儿NT值并作随访.结果 发育异常者28例, 其中NT值≥3 mm者24例(5例染色体核型异常、19例为结构异常但染色体核型正常);NT值<3 mm 4例, 其中结构异常者3例, 染色体核型异常者1例.胎儿NT值在不同孕周的差异具有统计学意义(P<0.05);正常胎儿NT值与孕妇年龄之间并无明显相关性(P>0.05).结论 NT增厚与胎儿发育异常之间有着密切的关联, 采用超声检测孕11~13+6周时胎儿NT厚度是胎儿畸形筛查的一项重要指标, 其检查较为方便和快捷, 具有无创性的优点, 值得予以推广.