葛根素自微乳制剂的制备工艺研究

摘要

目的:研究制备葛根素自微乳制剂.方法:根据葛根素的饱和溶解度选取油相、乳化剂和助乳化剂,通过伪三元相图,以自乳化效率及成乳后粒径为指标,确定最佳处方.结果:最佳处方为油酸乙酯∶吐温80/蓖麻油聚氧乙烯醚40(1∶2)∶聚乙二醇400∶葛根素∶三七总皂苷=15∶35∶35∶6∶9;微乳的平均粒径为32.9nm.结论:加入三七总皂苷的葛根素自微乳粒径小,稳定性好,这为自微乳制剂的增效减毒提供了新的思路和途径.%OBJECTIVE: To study on the preparation of Puerarin self-microemulsifying drug delivery system (SMEDDS). METHODS: The oil phase, emulsifier and auxiliary emulsifier were selected according to the saturation solubility of puerarin. The optimal formulation was determined by pseudo-ternary phase diagram using self-emulsifying efficiency and the emulsion particle size as the index. RESULTS: The optimal formulation was ethyl oleate:Tween-80/EL-40 (1:2):PEG 400:puerarin:PNS= 15:35 = 35:6 :9. The average diameter was 32.9 nm. CONCLUSION: Puerarin SMEDDS added into Panax pseudoginseng total saponins has small particle size and sound stability, which provides new idea and channel for efficacy-increasing and toxicity-reducing of SMEDDS prepration.