实施抗菌药物专项整治活动对改善清洁手术围术期预防用药合理性的效果的Meta分析

摘要

OBJECTIVE:To evaluate the antibiotics special rectification on rationality of prophylactic application of drugs for aseptic surgery.METHODS:Retrieved from CNKI,Wanfang database,VIP database,literatures about effects of antibiotics special rectification on rationality of prophylactic application of drugs for aseptic surgery published during 2011-2012 were included.Meta-analysis of included literatures was conducted with Rev Man 5.2 software.RESULTS:A total of 8 studies were included,involving 2706 patients.After the special rectification,the proportion of prophylactic application of drugs for aseptic surgery was lowered [RR=0.55,95％ CI(0.44,0.68),P＜0.01)],treatment course [RR=7.48,95％CI (3.19,17.54),P＜0.01)] and rationality of timing [RR=1.49,95 ％ CI (1.29,1.71),P＜ 0.01)] were all elevated to some extent,while the effects of antioiotics special rectificaton on postoperative infection is not satisfaction difference[RR=0.33,95％CI(0.03,3.11),P=0.33].CONCLUSIONS:The special rectification could improve the rationality of prophylactic application of drugs for aseptic surgery.More high quality literatures are required for further study.%目的:系统评价实施抗菌药物专项整治活动对改善清洁手术围术期预防用药合理性的效果.方法:计算机检索中国期刊全文数据库、万方数据库、中文科技期刊全文数据库等,纳入2011-2012年发表的关于实施抗菌药物专项整治活动对改善清洁手术围术期预防用药合理性的对照或随机对照研究,对符合纳入标准的研究采用Rev Man 5.2统计学软件进行Meta分析.结果:共纳入8项研究,合计2 706例患者.Meta分析结果显示,实施抗菌药物专项整治活动后,清洁手术围术期预防用药比例有所降低[RR=0.55,95％CI(0.44,0.68),P＜0.01)],用药时程[RR=7.48,95％CI(3.19,17.54),P＜0.01)]和用药时机[RR=1.49,95％CI(1.29,1.71),P＜0.01]的合理性有所提高；而在改善术后切口感染方面,实施抗菌药物专项整治活动前、后比较差异无统计学意义[RR=0.32,95％CI(0.03,3.11),P=0.33].结论:实施抗菌药物专项整治活动显著改善了清洁手术围术期预防用药的合理性,不仅降低了清洁手术围术期预防用药比例,还提高了用药时程和用药时机的合理性.