喜炎平注射液和利巴韦林注射液治疗普通型儿童手足口病的成本-效果分析

摘要

目的：比较喜炎平注射液与利巴韦林注射液治疗普通型儿童手足口病的成本-效果，为临床合理用药提供依据。方法：计算机检索中国知网、维普、万方、PubMed、Cochrane Library等数据库中关于喜炎平注射液治疗普通型儿童手足口病并以利巴韦林注射液为对照的研究文献，采用TreeAge Pro 2011构建决策树模型，对两种方案进行成本-效果分析，采用龙卷风图进行敏感因素分析并作单因素和双因素敏感度分析。结果与结论：喜炎平注射液和利巴韦林注射液治疗普通型儿童手足口病的总成本分别为2887.53元和3058.72元，总有效率分别为92.49％和78.12％，喜炎平注射液更具成本-效果优势。敏感度分析支持成本-效果分析结果。%OBJECTIVE:To compare cost-effectiveness of Xiyanping injection and Ribavirin injection in the treatment of com-mon type hand-foot-mouth disease (HFMD) in children,and to provide evidence for rational drug use in the clinic. METHODS:The literatures about Xiyanping injection in the treatment of common type HFMD in children using Ribavirin injection as control were retrieved from CNKI,VIP,Wanfang,PubMed,Cochrane library and other databases. The decision tree was established with TreeAge Pro 2011 software to conduct cost-effectiveness analysis. Tornado diagram was used to analyze sensitive factors;single fac-tor and double factors sensitivity analysis were also conducted. RESULTS & CONCLUSIONS:The total cost of Xiyanping injection and Ribavirin injection were 2 887.53 and 3 058.72 yuan,respectively. The total effective rates were 92.49% and 78.12%. Xiyan-ping injection shows cost-effectiveness advantage. The results of cost-effectiveness analysis were supported by sensitivity analysis.