目的:观察阿托伐他汀联合苯磺酸左旋氨氯地平治疗老年高血压合并颈动脉斑块的疗效和安全性.方法:160例老年高血压合并颈动脉斑块患者随机分为对照组(80例)和观察组(80例).对照组患者口服阿托伐他汀片3.0 mg,每日1次+复方利血平片2片,每日3次;观察组患者口服阿托伐他汀片(用法用量同对照组)+苯磺酸左旋氨氯地平片2.5 mg,每日1次.两组均连续治疗8个月.观察两组患者的降压疗效,治疗前后血压、颈动脉内膜中层厚度(IMT)水平及不良反应发生情况.结果:观察组患者降压总有效率显著高于对照组,差异有统计学意义(P0.05).治疗后,两组患者血压和IMT水平均显著低于同组治疗前,且观察组显著低于对照组,差异均有统计学意义(P0.05).结论:阿托伐他汀联合苯磺酸左旋氨氯地平治疗老年高血压合并颈动脉斑块降压疗效较好,可有效控制血压,改善颈动脉内膜水平,且不增加不良反应的发生.%OBJECTIVE:To observe the clinical efficacy and safety of atorvastatin combined with levamlodipine besylate in the treatment of elderly patients with hypertension combined with carotid plaque. METHODS:160 elderly patients with hyperten-sion combined with carotid plaque were randomly divided into control group(80 cases)and observation group(80 cases). Control group orally received Atorvastatin tablet 3 mg,qd+compound reserpine tablets 2 tablets,tid;observation group was received Atorv-astatin tablet(the same dosage and usage with control group)+Levamlodipine besylate tablet 2.5 mg,qd. They were treated for 8 months. Antihypertensive efficacy,blood pressure,and carotid intima-media thickness (IMT) before and after treatment,and the incidence of adverse reactions in 2 groups were observed and recorded. RESULTS:The antihypertensive effective rate in observa-tion group was significantly higher than control group,with statistical significance(P0.05). After treatment,blood pressure and IMT levels in 2 groups were significantly lower than before,and observation group was lower than control group,with statistical significance(P0.05). CONCLUSIONS:Atorv-astatin combined with levamlodipine besylate shows good efficacy in the treatment of elderly patients with hypertension combined with carotid plaque,which can not only effectively control patients'blood pressure,but also improve atherosclerosis,reversing plaques and does not increase the incidence of adverse veactions.
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